JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB165511

Recombinant Human GLT1D1 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human GLT1D1 protein is a Human Full Length protein, in the 1 to 266 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Glycosyltransferase 1 domain-containing protein 1, GLT1D1

1 Images
SDS-PAGE - Recombinant Human GLT1D1 protein (AB165511)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GLT1D1 protein (AB165511)

ab165511 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q96MS3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MRLLFLAVLRPHTGNAVTAQRVRAHLEAAGHVCVLKDAFDFESRSEIANLILAENCEAALALHLYRGGRLLQGHRIPFGVIFGGTDVNEDANQAEKNTVMGRVLEEARFAVAFTESMKEMAQAQWVDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIRKLEGSTED","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":266,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96MS3","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The GLT1D1 protein also known as solute carrier family 1 member 3 (SLC1A3 or EAAT1) serves as a glutamate transporter. It moves glutamate and aspartate across the cell membrane which is important for neurotransmission. The GLT1D1 protein has a molecular mass of about 59 kDa. This transporter is commonly expressed in the central nervous system particularly in astrocytes and plays a role in maintaining extracellular glutamate concentrations.
Biological function summary

The GLT1D1 protein supports the regulation of neurotransmitter levels in the synaptic cleft. It prevents excitotoxicity by removing excess glutamate therefore protecting neurons from damage. The protein can function within a multimeric complex often engaging in interactions that facilitate its transport activity. The transporter's activity ensures efficient communication between neurons in the central nervous system emphasizing its significance.

Pathways

The GLT1D1 protein integrates into the glutamatergic synapse pathway and the synaptic vesicle cycle. These pathways are significant for neurotransmitter release and uptake processes. The protein works closely with other transporters and receptors like NMDA receptors to modulate synaptic signaling. Its interplay in these pathways ensures that synaptic transmission proceeds without interruption supporting normal brain function.

The GLT1D1 protein has connections to neurological disorders such as epilepsy and Alzheimer's disease. Disruption in its function can lead to abnormal glutamate levels contributing to disease etiology. In epilepsy altered GLT1D1 function can influence seizure activity while in Alzheimer's imbalance in glutamate transport is linked to neurodegeneration. Its relationship with other proteins such as amyloid-beta peptides further highlights its involvement in Alzheimer's pathology.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Sequence similarities

Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

style
left-column

Product protocols

style
left-column

Target data

See full target information GLT1D1
style
left-column
style
left-column
style
right-column

Complementary Products

Biochemicals

AB120309

UCPH-101, Selective EAAT1 inhibitor

Chemical Structure - UCPH-101, Selective EAAT1 inhibitor (AB120309)

  • 0
  • 0
Primary Antibodies

AB205921

Anti-PD-L1 antibody [28-8]

BOND RX™ Validated|20ul selling size|Recombinant|KO Validated|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PD-L1 antibody [28-8] (AB205921)

  • 4
  • 15
Proteins & Peptides

AB165455

Recombinant Human ZNF358 protein

SDS-PAGE - Recombinant Human ZNF358 protein (AB165455)

  • 0
  • 0
Proteins & Peptides

AB165841

Recombinant Human UBR1 protein

SDS-PAGE - Recombinant Human UBR1 protein (AB165841)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com