Recombinant Human GLT1D1 protein is a Human Full Length protein, in the 1 to 266 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M R L L F L A V L R P H T G N A V T A Q R V R A H L E A A G H V C V L K D A F D F E S R S E I A N L I L A E N C E A A L A L H L Y R G G R L L Q G H R I P F G V I F G G T D V N E D A N Q A E K N T V M G R V L E E A R F A V A F T E S M K E M A Q A Q W V D P V F T R E V K A K V K R A A G V R L I G E M P Q E D L H A V V K N C F A V V N S S V S E G M S A A I L E A M D L E V P V L A R N I P G N A A V V K H E V T G L L F S N P Q E F V H L A K R L V S D P A L E K E I V V N G R E Y V R M Y H S W Q V E R D T Y Q Q L I R K L E G S T E D
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
Glycosyltransferase 1 domain-containing protein 1, GLT1D1
Recommended products
Recombinant Human GLT1D1 protein is a Human Full Length protein, in the 1 to 266 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q96MS3-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M R L L F L A V L R P H T G N A V T A Q R V R A H L E A A G H V C V L K D A F D F E S R S E I A N L I L A E N C E A A L A L H L Y R G G R L L Q G H R I P F G V I F G G T D V N E D A N Q A E K N T V M G R V L E E A R F A V A F T E S M K E M A Q A Q W V D P V F T R E V K A K V K R A A G V R L I G E M P Q E D L H A V V K N C F A V V N S S V S E G M S A A I L E A M D L E V P V L A R N I P G N A A V V K H E V T G L L F S N P Q E F V H L A K R L V S D P A L E K E I V V N G R E Y V R M Y H S W Q V E R D T Y Q Q L I R K L E G S T E D
- Accession
- Q96MS3
- Protein length
- Full Length
- Amino acids
- 1 to 266
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Sequence similarities
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The GLT1D1 protein also known as solute carrier family 1 member 3 (SLC1A3 or EAAT1) serves as a glutamate transporter. It moves glutamate and aspartate across the cell membrane which is important for neurotransmission. The GLT1D1 protein has a molecular mass of about 59 kDa. This transporter is commonly expressed in the central nervous system particularly in astrocytes and plays a role in maintaining extracellular glutamate concentrations.
- Biological function summary
The GLT1D1 protein supports the regulation of neurotransmitter levels in the synaptic cleft. It prevents excitotoxicity by removing excess glutamate therefore protecting neurons from damage. The protein can function within a multimeric complex often engaging in interactions that facilitate its transport activity. The transporter's activity ensures efficient communication between neurons in the central nervous system emphasizing its significance.
- Pathways
The GLT1D1 protein integrates into the glutamatergic synapse pathway and the synaptic vesicle cycle. These pathways are significant for neurotransmitter release and uptake processes. The protein works closely with other transporters and receptors like NMDA receptors to modulate synaptic signaling. Its interplay in these pathways ensures that synaptic transmission proceeds without interruption supporting normal brain function.
- Associated diseases and disorders
The GLT1D1 protein has connections to neurological disorders such as epilepsy and Alzheimer's disease. Disruption in its function can lead to abnormal glutamate levels contributing to disease etiology. In epilepsy altered GLT1D1 function can influence seizure activity while in Alzheimer's imbalance in glutamate transport is linked to neurodegeneration. Its relationship with other proteins such as amyloid-beta peptides further highlights its involvement in Alzheimer's pathology.
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1 product image
SDS-PAGE - Recombinant Human GLT1D1 protein (ab165511)
ab165511 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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Product protocols
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