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AB276609

Recombinant Human GLTP protein (His tag)

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Recombinant Human GLTP protein (His tag) is a Human Full Length protein, in the 1 to 209 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Glycolipid transfer protein, GLTP

1 Images
SDS-PAGE - Recombinant Human GLTP protein (His tag) (AB276609)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GLTP protein (His tag) (AB276609)

SDS-PAGE analysis of ab276609

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NZD2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV","proteinLength":"Full Length","predictedMolecularWeight":"26.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":209,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9NZD2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GLTP also known as Glycolipid Transfer Protein is an important mediator in lipid transfer processes. This protein has a molecular mass of approximately 24 kDa. It transports glycolipids within the cell facilitating their movement between membranes. GLTP is broadly expressed in various tissues with significant presence in the brain and other neural tissues. Specifically GLTP exhibits a strong affinity for glycosphingolipids which are important components of the cell membrane.
Biological function summary

The mechanism of GLTP involves the non-vesicular transfer of glycolipids acting independently of known vesicular transport systems. It doesn't form a complex with other proteins during its function instead it recognizes the lipid molecules directly. Through its action GLTP contributes to membrane structure and dynamics affecting several cellular processes such as signaling and cell recognition. Its function is significant in maintaining the balance of lipid composition in membranes.

Pathways

GLTP integrates into glycolipid biosynthesis and metabolism. It links with the glycosphingolipid pathway working alongside enzymes such as glucosylceramide synthase. This interaction influences ceramide transportation which impacts cell growth and apoptosis signaling pathways. These pathways are essential for maintaining proper cell behavior and function highlighting its importance in cellular homeostasis.

GLTP plays a role in neuropathological conditions. Disruptions in its function can lead to diseases such as Gaucher's disease which is characterized by glycolipid accumulation due to enzyme deficiencies. GLTP's interaction with enzymes like glucocerebrosidase is particularly relevant here as this association is known to affect disease progression. Furthermore studies suggest its involvement in neurodegenerative disorders linking it indirectly to proteins implicated in these diseases.
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General info

Function

Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.

Sequence similarities

Belongs to the GLTP family.

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Product protocols

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Target data

Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.
See full target information Glycolipid transfer protein
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Product promise

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