Recombinant Human Glucagon Receptor protein (Tagged)
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Recombinant Human Glucagon Receptor protein (Tagged) is a Human Fragment protein, in the 26 to 136 aa range, expressed in Mammalian, with >85%, suitable for SDS-PAGE.
View Alternative Names
Glucagon receptor, GL-R, GCGR
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Glucagon receptor activation primarily mediates glucose homeostasis by stimulating hepatic glucose production. It facilitates glycogenolysis and gluconeogenesis processes that increase blood glucose levels especially when glucose availability is low. The receptor does not operate in a complex but interacts closely with secondary messengers like cAMP (cyclic adenosine monophosphate) to trigger downstream signaling cascades. This action allows cells to respond quickly to changing hormonal signals in the bloodstream.
Pathways
Glucagon receptor is an important component of the glucagon signaling pathway and plays a part in the insulin resistance pathway. Upon activation by glucagon the receptor stimulates adenylate cyclase increasing cAMP production which activates protein kinase A (PKA). This process is closely linked with the insulin receptor pathway where both influence glucose and lipid metabolism balancing the metabolic responses within the liver and other tissues.
Specifications
Form
Liquid
General info
Function
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Sequence similarities
Belongs to the G-protein coupled receptor 2 family.
Post-translational modifications
Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding.
Target data
Complementary Products
Product promise
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