Recombinant Human Glucose Transporter GLUT2 protein is a Human Full Length protein, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M Y I G E I A P T A L R G A L G T F H Q L A I V T G I L I S Q I I G L E F I L G N Y D L W H I L L G L S G V R A I L Q S L L L F F C P E S P R Y L Y I K L D E E V K A K Q S L K R L R G Y D D V T K D I N E M R K E R E E A S S E Q K V S I I Q L F T N S S Y R Q P I L V A L M L H V A Q Q F S G I N G I F Y Y S T S I F Q T A G I S K P V Y A T I G V G A V N M V F T A V S V F L V E K A G R R S L F L I G M S G M F V C A I F M S V G L V L L N K F S W M S Y V S M I A I F L F V S F F E I G P G P I P W F M V A E F F S Q G P R P A A L A I A A F S N W T C N F I V A L C F Q Y I A D F C G P Y V F F L F A G V L L A F T L F T F F K V P E T K G K S F E E I A A E F Q K K S G S A H R P K A A V E M K F L G A T E T V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969).
Alternative names
GLUT2, SLC2A2, GLUT-2
Recommended products
Recombinant Human Glucose Transporter GLUT2 protein is a Human Full Length protein, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P11168-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M Y I G E I A P T A L R G A L G T F H Q L A I V T G I L I S Q I I G L E F I L G N Y D L W H I L L G L S G V R A I L Q S L L L F F C P E S P R Y L Y I K L D E E V K A K Q S L K R L R G Y D D V T K D I N E M R K E R E E A S S E Q K V S I I Q L F T N S S Y R Q P I L V A L M L H V A Q Q F S G I N G I F Y Y S T S I F Q T A G I S K P V Y A T I G V G A V N M V F T A V S V F L V E K A G R R S L F L I G M S G M F V C A I F M S V G L V L L N K F S W M S Y V S M I A I F L F V S F F E I G P G P I P W F M V A E F F S Q G P R P A A L A I A A F S N W T C N F I V A L C F Q Y I A D F C G P Y V F F L F A G V L L A F T L F T F F K V P E T K G K S F E E I A A E F Q K K S G S A H R P K A A V E M K F L G A T E T V
- Accession
- P11168
- Protein length
- Full Length
- Predicted molecular weight
- 65.5 kDa
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969).
- Sequence similarities
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
- Post-translational modifications
N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The glucose transporter GLUT2 also referred to as GLUT 2 GLUT-2 or GLUT2 transporter plays an important role in the movement of glucose across cell membranes. Mechanically it acts as a facilitative transporter allowing glucose and other monosaccharides to enter and exit cells. GLUT2 has a molecular weight of about 55 kDa. High expression of GLUT2 occurs in the liver pancreas kidney and intestines where it facilitates bidirectional glucose transport to maintain glucose balance.
- Biological function summary
The role of this transporter is important for glucose sensing and regulation. It is not part of any known complex but operates efficiently as a single unit within its membrane environment. In the pancreas GLUT2 detects blood glucose levels and initiates insulin release from beta cells. In the liver it enables glucose uptake during periods of high blood glucose and facilitates glucose production when blood glucose levels drop. By performing these functions GLUT2 helps maintain glucose homeostasis in the body.
- Pathways
GLUT2 is an essential component of glucose homeostasis and nutrient sensing pathways. It links to the insulin signaling pathway by facilitating insulin secretion in response to increased blood glucose. Furthermore GLUT2 associates with kinases such as AMPK which modulate cellular energy balance. The synergistic activity between GLUT2 and insulin signaling pathways highlights its central role in metabolic processes.
- Associated diseases and disorders
Altered GLUT2 function has significant implications. Mutations or deficiencies in GLUT2 can lead to conditions like Fanconi-Bickel syndrome a rare glycogen storage disorder. This transporter has been connected to diabetes as well due to its involvement in insulin secretion regulation. In both these instances GLUT2 interacts with other proteins such as glucokinase in the pancreas and liver highlighting its importance in disease pathology.
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1 product image
SDS-PAGE - Recombinant Human Glucose Transporter GLUT2 protein (ab152680)
12.5% SDS-PAGE analysis of ab152680 stained with Coomassie Blue.
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