Recombinant Human Glucose Transporter GLUT4 protein is a Human Full Length protein, in the 1 to 509 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Wheat germ
GST tag N-Terminus
ELISA, WB
No
M P S G F Q Q I G S E D G E P P Q Q R V T G T L V L A V F S A V L G S L Q F G Y N I G V I N A P Q K V I E Q S Y N E T W L G R Q G P E G P S S I P P G T L T T L W A L S V A I F S V G G M I S S F L I G I I S Q W L G R K R A M L V N N V L A V L G G S L M G L A N A A A S Y E M L I L G R F L I G A Y S G L T S G L V P M Y V G E I A P T H L R G A L G T L N Q L A I V I G I L I A Q V L G L E S L L G T A S L W P L L L G L T V L P A L L Q L V L L P F C P E S P R Y L Y I I Q N L E G P A R K S L K R L T G W A D V S G V L A E L K D E K R K L E R E R P L S L L Q L L G S R T H R Q P L I I A V V L Q L S Q Q L S G I N A V F Y Y S T S I F E T A G V G Q P A Y A T I G A G V V N T V F T L V S V L L V E R A G R R T L H L L G L A G M C G C A I L M T V A L L L L E R V P A M S Y V S I V A I F G F V A F F E I G P G P I P W F I V A E L F S Q G P R P A A M A V A G F S N W T S N F I I G M G F Q Y V A E A M G P Y V F L L F A V L L L G F F I F T F L R V P E T R G R T F D Q I S A A F H R T P S L L E Q E V K P S T E L E Y L G P D E N D
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
GLUT4, SLC2A4, GLUT-4
Recombinant Human Glucose Transporter GLUT4 protein is a Human Full Length protein, in the 1 to 509 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Wheat germ
GST tag N-Terminus
ELISA, WB
No
No
Human
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
M P S G F Q Q I G S E D G E P P Q Q R V T G T L V L A V F S A V L G S L Q F G Y N I G V I N A P Q K V I E Q S Y N E T W L G R Q G P E G P S S I P P G T L T T L W A L S V A I F S V G G M I S S F L I G I I S Q W L G R K R A M L V N N V L A V L G G S L M G L A N A A A S Y E M L I L G R F L I G A Y S G L T S G L V P M Y V G E I A P T H L R G A L G T L N Q L A I V I G I L I A Q V L G L E S L L G T A S L W P L L L G L T V L P A L L Q L V L L P F C P E S P R Y L Y I I Q N L E G P A R K S L K R L T G W A D V S G V L A E L K D E K R K L E R E R P L S L L Q L L G S R T H R Q P L I I A V V L Q L S Q Q L S G I N A V F Y Y S T S I F E T A G V G Q P A Y A T I G A G V V N T V F T L V S V L L V E R A G R R T L H L L G L A G M C G C A I L M T V A L L L L E R V P A M S Y V S I V A I F G F V A F F E I G P G P I P W F I V A E L F S Q G P R P A A M A V A G F S N W T S N F I I G M G F Q Y V A E A M G P Y V F L L F A V L L L G F F I F T F L R V P E T R G R T F D Q I S A A F H R T P S L L E Q E V K P S T E L E Y L G P D E N D
Full Length
1 to 509
Recombinant
GST tag N-Terminus
Liquid
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Sumoylated.
Dry Ice
-80°C
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
U+00A0;
U+00A0;
This supplementary information is collated from multiple sources and compiled automatically.
Glucose transporter GLUT4 also known as GLUT-4 or GLUT 4 transporter plays an important role in glucose uptake in cells. It is an insulin-responsive class I facilitated glucose transporter. GLUT4 predominantly expresses in insulin-sensitive tissues such as adipose tissue and skeletal and cardiac muscles. The functional transport mechanism facilitates glucose entry into the cell by translocating from intracellular vesicles to the plasma membrane in response to insulin stimulation. The molecular weight of GLUT4 is about 50 kDa and this property is often observed in techniques such as GLUT4 western blot where it aids in the identification of the transporter.
GLUT4 helps regulate blood sugar levels through its control over glucose uptake in muscle and adipose tissues. As an important component of the insulin-regulated glucose transport system GLUT4 responds to increased insulin levels by moving to the cell's surface aiding in glucose transportation into the cell. This adaptive response reduces blood glucose concentration after food intake. GLUT4 operates largely independently but may interact with other glucose transporters like GLUT1 to maintain normal cellular glucose homeostasis.
GLUT4 plays a significant role in the insulin signaling pathway and glucose homeostasis. Activation of the insulin receptor triggers a signaling cascade that includes enzymes like Akt (protein kinase B) which facilitates the translocation of GLUT4 vesicles to the plasma membrane. This translocation is important for glucose entry into the cells. Other key proteins in this pathway include IRS (insulin receptor substrate) proteins which act as signaling intermediates to link insulin receptor activation to downstream targets like GLUT4. Its activity is central to the maintenance of energy balance and storage in the body.
GLUT4 is closely associated with conditions like type 2 diabetes and obesity. Impaired GLUT4 function or expression can lead to decreased insulin sensitivity and glucose uptake contributing to the hyperglycemic state found in type 2 diabetes. Additionally obesity often presents a parallel decline in GLUT4 activity exacerbating insulin resistance. The regulation of GLUT4 is influenced by proteins such as insulin receptor and IRS proteins which when dysfunctional contribute to the pathogenesis of these metabolic disorders.
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ab159519 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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