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AB314522

Recombinant human GLUT9 protein (His tag)

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Recombinant human GLUT9 protein (His tag) is a Human Full Length protein, in the 1 to 540 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

GLUT9, SLC2A9, Glucose transporter type 9, Urate transporter, GLUT-9

1 Images
SDS-PAGE - Recombinant human GLUT9 protein (His tag) (AB314522)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human GLUT9 protein (His tag) (AB314522)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NRM0

Animal free

Yes

Carrier free

No

Species

Human

Reconstitution

Reconstitute in water

Storage buffer

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.87% Sodium chloride, 0.24% Tris, 0.05% 2-Octadecoxyethanol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20degC/-80degC. Our default final concentration of glycerol is 50%.
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Sequence info

[{"sequence":"MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP","proteinLength":"Full Length","predictedMolecularWeight":"60.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":540,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NRM0","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C|-80°C
Appropriate long-term storage conditions
-20°C|-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GLUT9 also known as SLC2A9 functions as a facilitative glucose transporter with a molecular weight of about 57 kDa. It is highly expressed in the kidneys and liver with lower levels of expression in other tissues such as the placenta and heart. GLUT9 facilitates the transport of uric acid glucose and fructose across the cell membrane playing an important role in cellular energy balance and metabolic processes.
Biological function summary

In the human body this protein influences urate homeostasis by managing uric acid levels in the blood. GLUT9 operates as a homomeric protein meaning it forms a functional unit by itself rather than needing to associate with other proteins to function. It significantly affects renal reabsorption processes regulating the excretion and reabsorption of urate in the kidneys. By controlling these uric acid levels it plays an important part in preventing hyperuricemia and related complications.

Pathways

GLUT9 contributes mainly to carbohydrate metabolism and urate transport pathways. Its role within the urate transport pathway links it to various other urate transporter proteins such as URAT1 which also participates in the regulation of uric acid excretion. In glucose metabolism GLUT9 works alongside other glucose transporters to maintain glucose levels linking it indirectly to pathways involving insulin response.

Elevated GLUT9 activity associates closely with conditions like gout and hyperuricemia. Due to its role in uric acid transport any dysfunction in GLUT9 can lead to increased serum uric acid contributing to gout development. Furthermore the interaction between GLUT9 and correlating proteins such as ABCG2 influences uric acid excretion processes connecting it to the pathological mechanisms underpinning these disorders. Researchers focus on these interactions to develop potential therapeutic strategies to manage related conditions effectively.
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Specifications

Form

Lyophilized

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General info

Function

High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed : 18327257, PubMed : 18701466, PubMed : 22647630, PubMed : 28083649, PubMed : 36749388). May have a residual high-affinity, low-capacity glucose and fructose transporter activity (PubMed : 18327257, PubMed : 18701466, PubMed : 18842065). Transports urate at rates 45- to 60-fold faster than glucose (PubMed : 18842065). Does not transport galactose (PubMed : 28083649). May mediate small uptake of adenine but not of other nucleobases (PubMed : 22647630).

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

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Product protocols

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Target data

High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed : 18327257, PubMed : 18701466, PubMed : 22647630, PubMed : 28083649, PubMed : 36749388). May have a residual high-affinity, low-capacity glucose and fructose transporter activity (PubMed : 18327257, PubMed : 18701466, PubMed : 18842065). Transports urate at rates 45- to 60-fold faster than glucose (PubMed : 18842065). Does not transport galactose (PubMed : 28083649). May mediate small uptake of adenine but not of other nucleobases (PubMed : 22647630).
See full target information SLC2A9
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Complementary Products

Primary Antibodies

AB223470

Anti-GLUT9 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GLUT9 antibody (AB223470)

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