Recombinant Human Glyt2 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The glycine transporter 2 often referred to as GlyT2 plays an important role mechanically. GlyT2 is responsible for the reuptake of glycine a neurotransmitter from the synaptic cleft back into presynaptic neurons. It is a membrane-bound protein with an approximate molecular mass of 85 kDa. GlyT2 is mostly expressed in the spinal cord and brainstem where it facilitates glycine neurotransmission essential for inhibitory signaling in the central nervous system.

Biological function summary

GlyT2 functions to maintain glycine homeostasis which is important for regulating inhibitory synaptic transmission. GlyT2 operates as part of a larger protein complex that efficiently recycles glycine into neurons which is essential for synaptic vesicle refilling. This recycling mechanism ensures a sufficient supply of glycine in synaptic vesicles contributing to the modulation of neuronal excitability and prevention of excessive excitatory neurotransmission.

Pathways

GlyT2 actively participates in the glycinergic synapse pathway which controls inhibitory neurotransmission. It complements the function of glycine receptors by ensuring sustained glycine availability. Related proteins involved in this pathway include GlyT1 another transporter which works alongside GlyT2 in glycine regulation. Additionally the function of GlyT2 is closely tied to the neurotransmitter release cycle pathway which manages synaptic neurotransmitter levels and synaptic signaling fidelity.

GlyT2 is linked to certain neurological conditions due to its role in regulating glycine levels. Hyperekplexia a genetic disorder characterized by exaggerated startle responses has been associated with mutations in the GlyT2 gene. Additionally GlyT2 might play a part in pain disorders where disrupted glycinergic transmission contributes to pathophysiology. In these conditions altered GlyT2 function impacts the balance of inhibitory and excitatory signals vital for normal sensory processing with GlyT2 interacting with proteins such as inhibitory glycine receptor alpha1 in these disorders.