Recombinant Human GMFG protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GMFG also known as Glia Maturation Factor Gamma is a protein involved in actin cytoskeleton reorganization. It has a molecular mass of approximately 17 kDa. GMFG is expressed in various tissues with notable presence in the nervous system and immune cells including microglia and dendritic cells. This protein aids in cell motility adhesion and morphological changes by promoting actin filament reorganization.

Biological function summary

GMFG plays a role in neurodevelopment and immune responses. It does not form part of a larger protein complex but works independently to influence cytoskeletal dynamics. GMFG affects the migration and activation of immune cells important for proper immune surveillance and response. It also participates in the development of neuronal structures by modulating actin filaments.

Pathways

GMFG interacts closely with actin-related signaling pathways. It influences the RAC1 and CDC42 pathways both critical for cytoskeletal rearrangements and cellular dynamics. Through these pathways GMFG collaborates with proteins like cofilin and profilin which also govern actin filament behavior. The interaction among these proteins facilitates controlled cell movement and signal transduction required for various cellular functions.

GMFG shows associations with neurodegenerative diseases and autoimmune conditions. Alterations in GMFG function potentially contribute to the pathogenesis of Alzheimer's disease by impacting neuronal architecture and glial cell activity. Additionally its role in immune cell dynamics connects GMFG to autoimmune disorders such as multiple sclerosis where its interaction with proteins like CXCR4 influences immune cell trafficking and function.