Recombinant Human GMPR1 protein (His tag N-Terminus)
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Recombinant Human GMPR1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 345 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
GMPR1, GMPR, GMP reductase 1, GMPR 1, Guanosine 5'-monophosphate oxidoreductase 1, Guanosine monophosphate reductase 1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human GMPR1 protein (His tag N-Terminus) (AB123163)
15% SDS-PAGE analysis of ab123163 (3 µg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
GMPR1 plays a critical role in purine metabolism by regulating the intracellular concentrations of guanine nucleotides. It does not work as part of a larger complex but functions independently to achieve its effects on nucleotide turnover. This protein ensures efficient recycling of guanine nucleotides which is important for cellular processes such as DNA and RNA synthesis signalling and energy metabolism.
Pathways
GMPR1 is involved mainly in the purine salvage pathway and the nucleotide degradation pathway. Through these pathways GMPR1 links with other proteins like hypoxanthine-guanine phosphoribosyltransferase (HGPRT) which also participates in nucleotide salvage. The balance achieved in these pathways is essential for cellular proliferation and energy conservation highlighting GMPR1's role in overall cellular homeostasis.
Specifications
Form
Liquid
Additional notes
ab123163 is purified using conventional chromatography techniques.
General info
Function
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Sequence similarities
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Target data
Complementary Products
Product promise
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