Recombinant Human GMPS protein is a Human Full Length protein, in the 1 to 693 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S H M A L C N G D S K L E N A G G D L K D G H H H Y E G A V V I L D A G A Q Y G K V I D R R V R E L F V Q S E I F P L E T P A F A I K E Q G F R A I I I S G G P N S V Y A E D A P W F D P A I F T I G K P V L G I C Y G M Q M M N K V F G G T V H K K S V R E D G V F N I S V D N T C S L F R G L Q K E E V V L L T H G D S V D K V A D G F K V V A R S G N I V A G I A N E S K K L Y G A Q F H P E V G L T E N G K V I L K N F L Y D I A G C S G T F T V Q N R E L E C I R E I K E R V G T S K V L V L L S G G V D S T V C T A L L N R A L N Q E Q V I A V H I D N G F M R K R E S Q S V E E A L K K L G I Q V K V I N A A H S F Y N G T T T L P I S D E D R T P R K R I S K T L N M T T S P E E K R K I I G D T F V K I A N E V I G E M N L K P E E V F L A Q G T L R P D L I E S A S L V A S G K A E L I K T H H N D T E L I R K L R E E G K V I E P L K D F H K D E V R I L G R E L G L P E E L V S R H P F P G P G L A I R V I C A E E P Y I C K D F P E T N N I L K I V A D F S A S V K K P H T L L Q R V K A C T T E E D Q E K L M Q I T S L H S L N A F L L P I K T V G V Q G D C R S Y S Y V C G I S S K D E P D W E S L I F L A R L I P R M C H N V N R V V Y I F G P P V K E P P T D V T P T F L T T G V L S T L R Q A D F E A H N I L R E S G Y A G K I S Q M P V I L T P L H F D R D P L Q K Q P S C Q R S V V I R T F I T S D F M T G I P A T P G N E I P V E V V L K M V T E I K K I P G I S R I M Y D L T S K P P G T T E W E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
Alternative names
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase, GMPS
Recommended products
Recombinant Human GMPS protein is a Human Full Length protein, in the 1 to 693 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P49915-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S H M A L C N G D S K L E N A G G D L K D G H H H Y E G A V V I L D A G A Q Y G K V I D R R V R E L F V Q S E I F P L E T P A F A I K E Q G F R A I I I S G G P N S V Y A E D A P W F D P A I F T I G K P V L G I C Y G M Q M M N K V F G G T V H K K S V R E D G V F N I S V D N T C S L F R G L Q K E E V V L L T H G D S V D K V A D G F K V V A R S G N I V A G I A N E S K K L Y G A Q F H P E V G L T E N G K V I L K N F L Y D I A G C S G T F T V Q N R E L E C I R E I K E R V G T S K V L V L L S G G V D S T V C T A L L N R A L N Q E Q V I A V H I D N G F M R K R E S Q S V E E A L K K L G I Q V K V I N A A H S F Y N G T T T L P I S D E D R T P R K R I S K T L N M T T S P E E K R K I I G D T F V K I A N E V I G E M N L K P E E V F L A Q G T L R P D L I E S A S L V A S G K A E L I K T H H N D T E L I R K L R E E G K V I E P L K D F H K D E V R I L G R E L G L P E E L V S R H P F P G P G L A I R V I C A E E P Y I C K D F P E T N N I L K I V A D F S A S V K K P H T L L Q R V K A C T T E E D Q E K L M Q I T S L H S L N A F L L P I K T V G V Q G D C R S Y S Y V C G I S S K D E P D W E S L I F L A R L I P R M C H N V N R V V Y I F G P P V K E P P T D V T P T F L T T G V L S T L R Q A D F E A H N I L R E S G Y A G K I S Q M P V I L T P L H F D R D P L Q K Q P S C Q R S V V I R T F I T S D F M T G I P A T P G N E I P V E V V L K M V T E I K K I P G I S R I M Y D L T S K P P G T T E W E
- Accession
- P49915
- Protein length
- Full Length
- Predicted molecular weight
- 79.2 kDa
- Amino acids
- 1 to 693
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab123202 is purified using conventional chromatography techniques.
General info
- Function
Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as GMP Synthase
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GMPS also known as guanine monophosphate synthetase is an enzyme with a mass of about 77 kDa. GMPS catalyzes the conversion of xanthosine monophosphate (XMP) to guanosine monophosphate (GMP) by utilizing an amide nitrogen from glutamine. This enzyme is important in the purine nucleotide biosynthesis pathway. GMPS is expressed in various tissues with high levels detected in proliferating cells due to their increased demand for nucleotide synthesis. It exists in forms such as GMP recombinant proteins and peptides.
- Biological function summary
GMPS plays a significant role in cell proliferation and metabolism. As part of the purine biosynthesis pathway GMPS functions at the branch point leading to the synthesis of GMP. It does not inherently form a complex but operates alongside several enzymes within the de novo purine synthesis pathway. This process is important in maintaining the cellular pools of guanine nucleotides which are building blocks for DNA and RNA.
- Pathways
GMPS is integrally involved in the purine biosynthesis and salvage pathways. These pathways are essential for nucleotide homeostasis and proper cell function. GMPS works in conjunction with enzymes like GMP reductase and adenylosuccinate synthetase sharing roles in nucleotide interconversion processes. Such interactions are vital for the cellular bioenergetics and nucleic acid metabolism.
- Associated diseases and disorders
GMPS has links to cancer progression and immune system dysfunction. The overexpression of GMPS can contribute to certain types of cancer due to increased nucleotide supplies that support rapid cell division. Abnormal GMPS function has correlations with immunological disorders because of its role in maintaining proper nucleotide levels necessary for immune cell proliferation. Associated proteins like GMP protein kinases play a part in regulating pathways influenced by GMPS activity highlighting its impact on disease states.
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1 product image
SDS-PAGE - Recombinant Human GMPS protein (ab123202)
15% SDS-PAGE showing ab123202 (3μg).
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