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AB268598

Recombinant human GNA14 protein (Tagged)

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Recombinant human GNA14 protein (Tagged) is a Human Full Length protein, in the 1 to 355 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

Guanine nucleotide-binding protein subunit alpha-14, G alpha-14, G-protein subunit alpha-14, GNA14

1 Images
SDS-PAGE - Recombinant human GNA14 protein (Tagged) (AB268598)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human GNA14 protein (Tagged) (AB268598)

SDS-PAGE analysis of ab268598.

MW ~66 kDa.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O95837

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAGCCCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDRKGFTKLVYQNIFTAMQAMIRAMDTLRIQYVCEQNKENAQIIREVEVDKVSMLSREQVEAIKQLWQDPGIQECYDRRREYQLSDSAKYYLTDIDRIATPSFVPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFLNSSVILFLNKKDLLEEKIMYSHLISYFPEYTGPKQDVRAARDFILKLYQDQNPDKEKVIYSHFTCATDTDNIRFVFAAVKDTILQLNLREFNLV","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":355,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O95837","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GNA14 also known as Guanine nucleotide-binding protein subunit alpha-14 is a component of the G protein family. This protein has a mass of approximately 41 kDa. It primarily expresses in the liver adrenal glands placenta and spleen. As a G protein it plays a role in signal transduction as part of the G alpha subunit which is an important player in relaying signals from cell surface receptors to downstream effectors within the cell.
Biological function summary

GNA14 mediates signal transduction by coupling with cell surface receptors to activate downstream signaling pathways. It functions as part of the larger heterotrimeric G protein complex interacting with G protein-coupled receptors (GPCRs). These GPCRs stimulate GNA14 which then activates intracellular signaling paths involved in various cellular responses including growth differentiation and metabolism playing an important role in maintaining cellular homeostasis.

Pathways

GNA14 participates mainly in the phospholipase C (PLC) signaling pathway where it interacts with PLC to regulate calcium ion release within the cells. This ion release affects various cellular processes such as muscle contraction and neurotransmitter release. GNA14 also shares pathway involvement with proteins like GNA13 another member of the G alpha subunit family which can have overlapping or distinct physiological roles.

GNA14 mutations have associations with conditions like uveal melanoma and Kaposiform hemangioendothelioma. In uveal melanoma GNA14 mutations affect normal signaling pathways leading to uncontrolled cell proliferation. In these diseases GNA14 does not work alone but interacts with other proteins involved in cancer pathway dysregulations such as GNAQ and BRAF implicating a complex network of molecular interactions in the pathology of such disorders.
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Specifications

Form

Liquid

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General info

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sequence similarities

Belongs to the G-alpha family. G(q) subfamily.

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Product protocols

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Target data

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
See full target information GNA14
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