Recombinant Human GNAZ protein (Tagged) is a Human Full Length protein, in the 2 to 355 aa range, expressed in Escherichia coli, with >70% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >70% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
G C R Q S S E E K E A A R R S R R I D R H L R S E S Q R Q R R E I K L L L L G T S N S G K S T I V K Q M K I I H S G G F N L E A C K E Y K P L I I Y N A I D S L T R I I R A L A A L R I D F H N P D R A Y D A V Q L F A L T G P A E S K G E I T P E L L G V M R R L W A D P G A Q A C F S R S S E Y H L E D N A A Y Y L N D L E R I A A A D Y I P T V E D I L R S R D M T T G I V E N K F T F K E L T F K M V D V G G Q R S E R K K W I H C F E G V T A I I F C V E L S G Y D L K L Y E D N Q T S R M A E S L R L F D S I C N N N W F I N T S L I L F L N K K D L L A E K I R R I P L T I C F P E Y K G Q N T Y E E A A V Y I Q R Q F E D L N R N K E T K E I Y S H F T C A T D T S N I Q F V F D A V T D V I I Q N N L K Y I G L C
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Alternative names
Guanine nucleotide-binding protein G(z) subunit alpha, G(x) alpha chain, Gz-alpha, GNAZ
Recommended products
Recombinant Human GNAZ protein (Tagged) is a Human Full Length protein, in the 2 to 355 aa range, expressed in Escherichia coli, with >70% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >70% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P19086-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.5
Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF
Sequence info
Amino acid sequence
- G C R Q S S E E K E A A R R S R R I D R H L R S E S Q R Q R R E I K L L L L G T S N S G K S T I V K Q M K I I H S G G F N L E A C K E Y K P L I I Y N A I D S L T R I I R A L A A L R I D F H N P D R A Y D A V Q L F A L T G P A E S K G E I T P E L L G V M R R L W A D P G A Q A C F S R S S E Y H L E D N A A Y Y L N D L E R I A A A D Y I P T V E D I L R S R D M T T G I V E N K F T F K E L T F K M V D V G G Q R S E R K K W I H C F E G V T A I I F C V E L S G Y D L K L Y E D N Q T S R M A E S L R L F D S I C N N N W F I N T S L I L F L N K K D L L A E K I R R I P L T I C F P E Y K G Q N T Y E E A A V Y I Q R Q F E D L N R N K E T K E I Y S H F T C A T D T S N I Q F V F D A V T D V I I Q N N L K Y I G L C
- Accession
- P19086
- Protein length
- Full Length
- Amino acids
- 2 to 355
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
- Sequence similarities
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GNAZ also known as Guanine nucleotide-binding protein G(z) subunit alpha functions as a modulator or transducer in various transmembrane signaling systems. The protein plays an essential role in coupling cell surface receptors to intracellular signaling pathways. GNAZ weighs approximately 41.5 kDa and is widely expressed in human brain tissues and certain neuroendocrine tissues.
- Biological function summary
GNAZ connects with receptor-mediated signal transduction aiding in neurotransmitter release and sensory perception. GNAZ functions as part of the heterotrimeric G-protein complex which includes G beta and G gamma subunits. This protein often regulates signal transduction cascades that influence cellular responses to external stimuli.
- Pathways
GNAZ is closely linked to important signaling pathways such as the serotonergic signaling pathway and the phototransduction pathway. Within these pathways GNAZ interacts with kinases and ion channels influencing cellular responses and synaptic functions. GNAZ works alongside related proteins such as GNAI and GNAT contributing to the regulation of neurotransmitter systems.
- Associated diseases and disorders
GNAZ relates to neurological disorders and certain psychiatric conditions including schizophrenia and bipolar disorder. Changes in the activity or expression of GNAZ may impact neurotransmitter systems which are fundamental to these conditions. Through these disorders GNAZ connects with proteins like GNB and GNG pointing to its involvement in signal processing abnormalities that underlie these diseases.
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1 product image
SDS-PAGE - Recombinant Human GNAZ protein (Tagged) (ab268603)
SDS-PAGE analysis of ab268603.
MW ~65 kDa.
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Product protocols
- Visit the general protocols
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