Recombinant Human GNG11 protein (His tag) is a Human Full Length protein, in the 1 to 70 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M P A L H I E D L P E K E K L K M E V E Q L R K E V K L Q R Q Q V S K C S E E I K N Y I E E R S G E D P L V K G I P E D K N P F K E K G S C
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Alternative names
GNGT11, GNG11, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Recommended products
Recombinant Human GNG11 protein (His tag) is a Human Full Length protein, in the 1 to 70 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- P61952-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M P A L H I E D L P E K E K L K M E V E Q L R K E V K L Q R Q Q V S K C S E E I K N Y I E E R S G E D P L V K G I P E D K N P F K E K G S C
- Accession
- P61952
- Protein length
- Full Length
- Predicted molecular weight
- 10.6 kDa
- Amino acids
- 1 to 70
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab177606 was purified using conventional chromatography techniques.
General info
- Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
- Sequence similarities
Belongs to the G protein gamma family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GNG11 also known as Guanine nucleotide-binding protein gamma-11 belongs to the gamma subunit family of G-proteins involved in cell signaling. It has a molecular mass of approximately 8 kDa. GNG11 forms part of the heterotrimeric G-protein complex playing a role in transmitting chemical signals from outside the cell to its interior. Researchers find GNG11 expressed in various tissues including the brain heart and liver.
- Biological function summary
GNG11 interacts with both the beta and alpha subunits within the G-protein complex to mediate signaling processes. It facilitates communication between receptors and downstream effectors influencing cellular responses. GNG11's presence in diverse cellular environments indicates it assists in modulating critical physiological processes like neurotransmission cardiac function and metabolic regulation.
- Pathways
GNG11 integrates into the G-protein-coupled receptor (GPCR) signaling pathway. This pathway plays a significant role in signal transduction affecting cellular response to external stimuli. GNG11 functions alongside related proteins like GNB1 (beta subunit) and a variety of G-protein alpha subunits influencing pathways linked to cyclic AMP production and phosphatidylinositol signaling. These pathways play important roles in diverse physiological processes including hormone response and sensory perception.
- Associated diseases and disorders
Certain research connects dysregulation of GNG11 with specific pathologies such as cardiovascular disease and neurodegenerative disorders. Alterations in G-protein signaling pathways where GNG11 is a component may contribute to these conditions. Scientists explore its interactions with proteins like ATF6 which can influence the development or progression of these disorders providing potential therapeutic targets for intervention.
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1 product image
SDS-PAGE - Recombinant Human GNG11 protein (His tag) (ab177606)
15% SDS-PAGE analysis of ab177606 (3 μg).
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