Recombinant Human GNG11 protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GNG11 also known as Guanine nucleotide-binding protein gamma-11 belongs to the gamma subunit family of G-proteins involved in cell signaling. It has a molecular mass of approximately 8 kDa. GNG11 forms part of the heterotrimeric G-protein complex playing a role in transmitting chemical signals from outside the cell to its interior. Researchers find GNG11 expressed in various tissues including the brain heart and liver.

Biological function summary

GNG11 interacts with both the beta and alpha subunits within the G-protein complex to mediate signaling processes. It facilitates communication between receptors and downstream effectors influencing cellular responses. GNG11's presence in diverse cellular environments indicates it assists in modulating critical physiological processes like neurotransmission cardiac function and metabolic regulation.

Pathways

GNG11 integrates into the G-protein-coupled receptor (GPCR) signaling pathway. This pathway plays a significant role in signal transduction affecting cellular response to external stimuli. GNG11 functions alongside related proteins like GNB1 (beta subunit) and a variety of G-protein alpha subunits influencing pathways linked to cyclic AMP production and phosphatidylinositol signaling. These pathways play important roles in diverse physiological processes including hormone response and sensory perception.

Certain research connects dysregulation of GNG11 with specific pathologies such as cardiovascular disease and neurodegenerative disorders. Alterations in G-protein signaling pathways where GNG11 is a component may contribute to these conditions. Scientists explore its interactions with proteins like ATF6 which can influence the development or progression of these disorders providing potential therapeutic targets for intervention.