Recombinant Human GOLGA7 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GOLGA7 also known as Golgi autoantigen is a small protein with a mass of approximately 15 kDa. It is expressed in a wide variety of tissues with notable expression in the Golgi apparatus where it plays a role in maintaining its structure and function. GOLGA7 participates in membrane trafficking within the Golgi by contributing to the organization and stabilization of the Golgi architecture.

Biological function summary

This protein assists in the formation and maintenance of the Golgi ribbon a structure necessary for proper cellular function. GOLGA7 associates with GOLGA7B forming a complex that facilitates interaction with other Golgi-resident proteins. This interaction supports the precise cargo transport processes that are essential for cellular homeostasis. The protein’s role within the complex highlights its essential position in cellular logistics.

Pathways

The involvement of GOLGA7 in the Golgi apparatus influences membrane trafficking pathways. It plays a significant role in the vesicle-mediated transport process and interacts with proteins such as ZDHHC9 within these pathways. These interactions are important for the correct localization and function of transported proteins impacting processes like signal transduction and protein glycosylation.

GOLGA7 has been implicated in conditions like cancer and congenital disorders of glycosylation. Changes in GOLGA7 expression or function can lead to disruptions in normal cellular transport processes contributing to disease pathogenesis. Additionally its interaction with proteins such as RAS can influence oncogenic pathways linking it to tumorigenesis. Understanding these connections can aid in developing targeted therapies for related conditions.