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AB153211

Recombinant Human GP210 protein

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Recombinant Human GP210 protein is a Human Full Length protein, in the 1 to 967 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA0906, PSEC0245, NUP210, Nuclear pore membrane glycoprotein 210, Nuclear pore protein gp210, Nuclear envelope pore membrane protein POM 210, Nucleoporin Nup210, Pore membrane protein of 210 kDa, POM210

1 Images
SDS-PAGE - Recombinant Human GP210 protein (AB153211)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GP210 protein (AB153211)

ab153211 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q8TEM1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAARGRGLLLLTLSVLLAAGPSAAAAKLNIPKVLLPFTRATRVNFTLEASEGCYRWLSTRPEVASIEPLGLDEQQCSQKAVVQARLTQPARLTSIIFAEDITTGQVLRCDAIVDLIHDIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFEWTIVKDSEADRFSDSHNALRILTFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKLKARIQEAVYKNVRPAEVRLLILENILLNPAYDVYLMVGTSIHYKVQKIRQGKITELSMPSDQYELQLQNSIPGPEGDPARPVAVLAQDTSMVTALQLGQSSLVLGHRSIRMQGASRLPNSTIYVVEPGYLGFTVHPGDRWVLETGRLYEITIEVFDKFSNKVYVSDNIRIETVLPAEFFEVLSSSQNGSYHRIRALKRGQTAIDAALTSVVDQDGGVHILQVPVWNQQEVEIHIPITLYPSILTFPWQPKTGAYQYTIRAHGGSGNFSWSSSSHLVATVTVKGVMTTGSDIGFSVIQAHDVQNPLHFGEMKVYVIEPHSMEFAPCQVEARVGQALELPLRISGLMPGGASEVVTLSDCSHFDLAVEVENQGVFQPLPGRLPPGSEHCSGIRVKAEAQGSTTLLVSYRHGHVHLSAKITIAAYLPLKAVDPSSVALVTLGSSKEMLFEGGPRPWILEPSKFFQNVTAEDTDSIGLALFAPHSSRNYQQHWILVTCQALGEQVIALSVGNKPSLTNPFPAVEPAVVKFVCAPPSRLTLAPVYTSPQLDMSCPLLQQNKQVVPVSSHRNPRLDLAAYDQEGRRFDNFSSLSIQWESTRPVLASIEPELPMQLVSQDDESGQKKLHGLQAILVHEASGTTAITATATGYQESHLSSARTKQPHDPLVPLSASIELILVEDVRVSPEEVTIYNHPGIQAELRIREGSGYFFLNTSTADVVKVAYQEARGVAMVSLGHRSPLLVFIPYLGCCVVN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":967,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8TEM1","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GP210 also known as Nup210 is a critical component of the nuclear pore complex with a molecular mass of approximately 210 kDa. This integral membrane protein is primarily expressed in the nuclear envelope of eukaryotic cells. GP210 plays a significant mechanical role in the structural integrity of the nuclear pore complex a pivotal gateway for nucleocytoplasmic transport. Its localization at the nuclear envelope suggests its importance in maintaining the selective barrier and facilitating transport functions between the nucleus and the cytoplasm.
Biological function summary

GP210 is involved in the regulation of nuclear-cytoplasmic transport and acts as a scaffold for various transport machinery components. As a member of the nuclear pore complex it interacts with other nucleoporins forming a channel that allows the passage of molecules between the nucleus and cytoplasm. GP210 participates in processes related to genome regulation influencing gene expression by modulating nuclear import/export cycles. Alterations in GP210 function can have implications for the cell cycle and differentiation processes.

Pathways

GP210 engages in the nucleocytoplasmic transport pathway which is essential for the transport of macromolecules such as RNA and proteins. This pathway is closely related to the Ran GTPase cycle where GP210 plays a supporting role in maintaining the directionality of the transport. It interacts with transport factors such as importins and exportins ensuring the precise regulation of molecular traffic. GP210's involvement ties it to key cellular functions and highlights its critical role in cellular homeostasis and signal transduction.

Aberrant function or expression of GP210 has been implicated in autoimmune diseases such as primary biliary cholangitis (PBC). Autoantibodies against GP210 are often detected in patients with PBC indicating its role in the pathogenesis of this autoimmune liver disorder. Furthermore GP210 is associated with certain cancer types where its dysregulation might contribute to tumorigenesis and cancer progression. In these contexts GP210 could interact with oncogenic or tumor suppressor proteins highlighting its potential as a biomarker and target for therapeutic intervention.
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Specifications

Form

Liquid

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General info

Function

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

Sequence similarities

Belongs to the NUP210 family.

Post-translational modifications

N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).. Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.
See full target information NUP210
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Complementary Products

Primary Antibodies

AB111947

Anti-GST antibody [EPR4236]

RabMAb|Recombinant|Lab Essentials

Western blot - Anti-GST antibody [EPR4236] (AB111947)

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Primary Antibodies

AB52894

Anti-EGFR antibody [EP38Y]

BOND RX™ Validated|KO Validated|RabMAb|Lab Essentials|20ul selling size|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFR antibody [EP38Y] (AB52894)

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Cell Lines & Lysates

AB266492

Human NUP210 (GP210) knockout HEK-293T cell line

Advanced Validation

Western blot - Human NUP210 (GP210) knockout HEK-293T cell line (AB266492)

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Cell Lines & Lysates

AB258549

Human NUP210 (GP210) knockout HEK-293T cell lysate

Western blot - Human NUP210 (GP210) knockout HEK-293T cell lysate (AB258549)

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Product promise

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