Recombinant Human GPCR C5L2 protein is a Human Full Length protein, in the 1 to 337 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
Amino acid sequence
M G N D S V S Y E Y G D Y S D L S D R P V D C L D G A C L A I D P L R V A P L P L Y A A I F L V G V P G N A M V A W V A G K V A R R R V G A T W L L H L A V A D L L C C L S L P I L A V P I A R G G H W P Y G A V G C R A L P S I I L L T M Y A S V L L L A A L S A D L C F L A L G P A W W S T V Q R A C G V Q V A C G A A W T L A L L L T V P S A I Y R R L H Q E H F P A R L Q C V V D Y G G S S S T E N A V T A I R F L F G F L G P L V A V A S C H S A L L C W A A R R C R P L G T A I V V G F F V C W A P Y H L L G L V L T V A A P N S A L L A R A L R A E P L I V G L A L A H S C L N P M L F L Y F G R A Q L R R S L P A A C H W A L R E S Q G Q D E S V D S K K S T S H D L V S E M E V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
Alternative names
C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G-protein coupled receptor 77, GPR77, C5L2, C5AR2
Recommended products
Recombinant Human GPCR C5L2 protein is a Human Full Length protein, in the 1 to 337 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
Wheat germ
- Tags
GST tag N-Terminus
- Applications
ELISA, WB
- Biologically active
No
- Accession
- Q9P296-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
M G N D S V S Y E Y G D Y S D L S D R P V D C L D G A C L A I D P L R V A P L P L Y A A I F L V G V P G N A M V A W V A G K V A R R R V G A T W L L H L A V A D L L C C L S L P I L A V P I A R G G H W P Y G A V G C R A L P S I I L L T M Y A S V L L L A A L S A D L C F L A L G P A W W S T V Q R A C G V Q V A C G A A W T L A L L L T V P S A I Y R R L H Q E H F P A R L Q C V V D Y G G S S S T E N A V T A I R F L F G F L G P L V A V A S C H S A L L C W A A R R C R P L G T A I V V G F F V C W A P Y H L L G L V L T V A A P N S A L L A R A L R A E P L I V G L A L A H S C L N P M L F L Y F G R A Q L R R S L P A A C H W A L R E S Q G Q D E S V D S K K S T S H D L V S E M E V
- Accession
- Protein length
Full Length
- Amino acids
1 to 337
- Nature
Recombinant
- Tags
GST tag N-Terminus
Specifications
- Form
Liquid
General info
- Function
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
- Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Storage
- Shipped at conditions
Dry Ice
- Appropriate short-term storage conditions
-80°C
- Appropriate long-term storage conditions
-80°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
U+00A0;
U+00A0;
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The G-protein-coupled receptor C5L2 also known as GPR77 is a member of the GPCR family a large group of cell surface receptors essential for signal transduction. It is a glycoprotein with a molecular mass of around 39 kDa. This receptor does not share typical signaling properties with classical GPCRs as it lacks G-protein activation function. Instead it acts as a decoy receptor. C5L2 is widely expressed in adipose tissue macrophages and other immune cells with an abundant presence in the lungs liver and spleen.
- Biological function summary
C5L2 participates in immune response modulation lipid metabolism and inflammation resolution. This receptor does not operate as part of a known complex but plays a critical role in complement cascade regulation. It binds complement component C5a and its inactivated form C5a des-Arg which is a significant function distinguishing it from other receptors. C5L2 may act to sequester these components thereby limiting excessive inflammatory responses and sustaining homeostasis.
- Pathways
This receptor is involved in the complement and the adipokine signaling pathways. C5L2 interacts within the complement system to mediate the immune response functioning alongside other components such as C5aR1. Its presence in the adipokine pathway suggests a role in energy metabolism hinting at the regulation of glucose and lipid homeostasis in adipose tissues and potentially engaging interactions with proteins like adiponectin.
- Associated diseases and disorders
C5L2 associates with conditions like sepsis and metabolic syndrome. In sepsis C5L2's regulation of the complement pathway influences inflammatory responses and outcomes. The association of C5L2 with metabolic syndrome implicates its involvement in dysregulated adipokine signaling suggesting a direct relationship with proteins such as C5aR1 in these contexts. Understanding C5L2's function provides insights into therapeutic targets for these diseases.
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1 product image
SDS-PAGE - Recombinant Human GPCR C5L2 protein (ab153291)
ab153291 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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