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AB116876

Recombinant Human GPCR GPR12 protein (GST tag N-Terminus)

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Recombinant Human GPCR GPR12 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 334 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

G-protein coupled receptor 12, GPR12

1 Images
SDS-PAGE - Recombinant Human GPCR GPR12 protein (GST tag N-Terminus) (AB116876)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GPCR GPR12 protein (GST tag N-Terminus) (AB116876)

12.5% SDS-PAGE showing ab116876 at approximately 62.81kDa stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB, SDS-PAGE

applications

Biologically active

No

Accession

P47775

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Recombinant protein.</p>" } } }
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Sequence info

[{"sequence":"MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV","proteinLength":"Full Length","predictedMolecularWeight":"62.81 kDa","actualMolecularWeight":null,"aminoAcidEnd":334,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P47775","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPCR GPR12 also known as G-protein coupled receptor 12 is a member of the GPCR family which controls many physiological processes by transmitting signals across the cell membrane. It consists of around 370 amino acids giving it an approximate mass of 42 kDa. GPR12 is expressed in the central nervous system particularly in the brain with some expression noted in peripheral tissues such as the testes. The receptor activates several G proteins upon stimulation by ligands influencing a variety of downstream cellular responses.
Biological function summary

GPR12 influences cellular processes related to neurodevelopment and neuronal differentiation. It contributes to the regulation of neuronal growth offering support to synaptic connectivity and plasticity. This receptor may operate as part of a signaling complex although its specific complex partners remain unspecified. Its activity promotes cell survival pathways indicating its broader role in maintaining proper function of neural cells.

Pathways

Some cells utilize GPR12 within the lipid signaling and neurotrophic pathways. GPR12 interacts with cyclic adenosine monophosphate (cAMP) as part of the lipid signaling pathway influencing cellular metabolism and growth. Another critical interaction involves its cross-talk with neurotrophic factors like brain-derived neurotrophic factor (BDNF) highlighting its relevance in neural health and responsiveness to environmental changes.

Research links GPR12 to neurological conditions such as Alzheimer's disease and mood disorders. Its dysregulation affects synaptic function and may exacerbate neurodegenerative processes in Alzheimer's. Moreover GPR12 interacts with proteins like amyloid precursor protein (APP) in the context of Alzheimer's pathology. Abnormal expression of GPR12 might also disrupt mood regulation connecting it to proteins like serotonin receptors linking to mood disorders.
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Specifications

Form

Liquid

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General info

Function

Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Product protocols

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Target data

Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.
See full target information GPR12
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Product promise

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