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AB289774

Recombinant Human GPCR GPR146 protein

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Recombinant Human GPCR GPR146 protein is a Human Full Length protein, in the 1 to 333 aa range, expressed in Cell free, with >90%, suitable for SDS-PAGE.

View Alternative Names

PGR8, GPR146, G-protein coupled receptor 146, G-protein coupled receptor PGR8

1 Images
SDS-PAGE - Recombinant Human GPCR GPR146 protein (AB289774)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GPCR GPR146 protein (AB289774)

SDS-PAGE analysis of ab289774

Key facts

Purity

>90% SDS-PAGE

Expression system

Cell free

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96CH1

Animal free

Yes

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.79% Sodium chloride, 0.14% Disodium hydrogenorthophosphate, 0.05% 2-Octadecoxyethanol, 0.024% Potassium phosphate monobasic, 0.02% Potassium chloride

storage-buffer

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MWSCSWFNGTGLVEELPACQDLQLGLSLLSLLGLVVGVPVGLCYNALLVLANLHSKASMTMPDVYFVNMAVAGLVLSALAPVHLLGPPSSRWALWSVGGEVHVALQIPFNVSSLVAMYSTALLSLDHYIERALPRTYMASVYNTRHVCGFVWGGALLTSFSSLLFYICSHVSTRALECAKMQNAEAADATLVFIGYVVPALATLYALVLLSRVRREDTPLDRDTGRLEPSAHRLLVATVCTQFGLWTPHYLILLGHTVIISRGKPVDAHYLGLLHFVKDFSKLLAFSSSFVTPLLYRYMNQSFPSKLQRLMKKLPCGDRHCSPDHMGVQQVLA","proteinLength":"Full Length","predictedMolecularWeight":"37.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":333,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"Q96CH1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

G protein-coupled receptor 146 commonly known as GPCR GPR146 is a member of the extensive GPCR family involved in cell signaling. It weighs approximately 42 kDa. GPR146 is located on the cell membrane mainly expressed in the brain and heart tissues. This protein like other GPCRs works by activating intracellular signal transduction pathways in response to extracellular signals.
Biological function summary

GPCR GPR146 binds with specific ligands initiating a signaling cascade that affects cellular responses. While no solid evidence indicates that GPR146 forms part of a complex it seems to interact with G proteins. This interaction stimulates secondary messenger pathways which can modulate various physiological processes.

Pathways

GPR146 is implicated in the G protein signaling pathway influencing processes like neurotransmission and cardiovascular regulation. It maintains connections with other proteins in these pathways such as G proteins and adenylate cyclases which are important for propagating signal transduction events within the cell ultimately influencing cellular responses.

GPCR GPR146 has been linked to atherosclerosis and cardiovascular diseases. Alterations in GPCR GPR146 could disrupt normal signal transduction contributing to these conditions. It shows relations to other proteins involved in these disorders such as LDL receptors which highlights its significance in lipid metabolism and cardiovascular health.
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Specifications

Form

Lyophilized

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General info

Function

G-protein coupled receptor required for the regulation of plasma cholesterol levels (PubMed : 31778654, PubMed : 38503280). Receptor for cholesin, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed : 38503280).

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Product protocols

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Target data

G-protein coupled receptor required for the regulation of plasma cholesterol levels (PubMed : 31778654, PubMed : 38503280). Receptor for cholesin, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed : 38503280).
See full target information GPR146
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