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AB158567

Recombinant Human GPCR GPR31 protein (GST tag N-Terminus)

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Recombinant Human GPCR GPR31 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 319 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

12-(S)-HETE receptor, 12-HETER, G-protein coupled receptor 31, GPR31/12-HETER, GPR31

1 Images
SDS-PAGE - Recombinant Human GPCR GPR31 protein (GST tag N-Terminus) (AB158567)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human GPCR GPR31 protein (GST tag N-Terminus) (AB158567)

ab158567 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

O00270

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB75579

Anti-GPCR GPR31 antibody

Western blot - Anti-GPCR GPR31 antibody (AB75579)

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Proteins & Peptides

AB152435

Recombinant Human GPCR GPR39 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human GPCR GPR39 protein (GST tag N-Terminus) (AB152435)

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Proteins & Peptides

AB162723

Recombinant Human GPCR GPR85 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human GPCR GPR85 protein (GST tag N-Terminus) (AB162723)

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Proteins & Peptides

AB116876

Recombinant Human GPCR GPR12 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human GPCR GPR12 protein (GST tag N-Terminus) (AB116876)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPFPNCSAPSTVVATAVGVLLGLECGLGLLGNAVALWTFLFRVRVWKPYAVYLLNLALADLLLAACLPFLAAFYLSLQAWHLGRVGCWALRFLLDLSRSVGMAFLAAVALDRYLRVVHPRLKVNLLSPQAALGVSGLVWLLMVALTCPGLLISEAAQNSTRCHSFYSRADGSFSIIWQEALSCLQFVLPFGLIVFCNAGIIRALQKRLREPEKQPKLQRAQALVTLVVVLFALCFLPCFLARVLMHIFQNLGSCRALCAVAHTSDVTGSLTYLHSVLNPVVYCFSSPTFRSSYRRVFHTLRGKGQAAEPPDFNPRDSYS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":319,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O00270","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR31 also known as G protein-coupled receptor 31 is a member of the GPCR family. This receptor has a mass of approximately 35 kDa. It is widely expressed in human tissues with notable expression in the brain liver and immune cells. GPR31 plays a significant role in transmitting extracellular signals through the cell membrane activating intracellular G proteins and triggering various signaling pathways.
Biological function summary

GPR31 influences cellular processes such as growth and response to environmental changes. It does not associate with a specific complex but interacts with several intracellular signaling molecules. Its function in immune cells suggests a role in immunoregulation and inflammation. Additionally GPR31 might have effects on cell proliferation and migration especially in liver and cancer cells.

Pathways

GPR31 directly influences the arachidonic acid and leukotriene B4 signaling pathways. These pathways regulate inflammation and immune responses. GPR31 interacts with specific proteins like GPR120 and CB2 receptors. Its role within these pathways suggests potential implications in inflammatory diseases and conditions linked to overactive immune responses.

GPR31 has significant relevance to liver cancer and inflammatory bowel disease. Research links GPR31 to the progression of liver cancer by affecting cancer cell proliferation and migration. It also plays a role in the dysregulation of inflammatory responses in bowel diseases via its interaction with CB2 receptors and pathways influenced by inflammation.
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Specifications

Form

Liquid

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General info

Function

High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (PubMed : 21712392, PubMed : 29227475). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes (PubMed : 26965684, PubMed : 28619714, PubMed : 29227475). 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways leading to cell growth (PubMed : 21712392, PubMed : 29227475). Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (PubMed : 28619714). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens (By similarity). Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury (PubMed : 29227475).. Proton-sensing G protein-coupled receptor.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Product protocols

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Target data

High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (PubMed : 21712392, PubMed : 29227475). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes (PubMed : 26965684, PubMed : 28619714, PubMed : 29227475). 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways leading to cell growth (PubMed : 21712392, PubMed : 29227475). Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (PubMed : 28619714). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens (By similarity). Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury (PubMed : 29227475).. Proton-sensing G protein-coupled receptor.
See full target information 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
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