Recombinant Human GPCR GPR39 protein
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Recombinant Human GPCR GPR39 protein is a Human Full Length protein, in the 1 to 453 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
View Alternative Names
G-protein coupled receptor 39, GPR39
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human GPCR GPR39 protein (AB152435)
12.5% SDS-PAGE analysis of ab152435 stained with Coomassie Blue.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
GPR39 influences various physiological processes related to metabolic and homeostatic functions in the body. It is not part of a complex but operates as a standalone receptor that activates diverse intracellular pathways upon ligand binding. The receptor has reported roles in regulating appetite influencing glucose metabolism and maintaining energy balance. Through the modulation of different cellular signals GPR39 helps in controlling processes like gastric acid secretion and insulin sensitivity.
Pathways
Researchers recognize GPR39’s involvement in the Wnt signaling and mTOR signaling pathways. In the context of the Wnt pathway GPR39 interfaces through interactions with other signaling molecules and proteins like beta-catenin which underpins its role in cellular growth and differentiation. Meanwhile in the mTOR pathway its interaction influences protein synthesis and cellular metabolism. These pathways highlight the receptor's pivotal role in various biological processes.
Specifications
Form
Liquid
General info
Function
Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death (PubMed : 18180304). Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (PubMed : 20522546). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner (PubMed : 18180304). Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity : HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (PubMed : 26365466).
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Target data
Complementary Products
Product promise
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