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AB165129

Recombinant Human GPCR MRGX2 protein

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(1 Publication)

Recombinant Human GPCR MRGX2 protein is a Human Full Length protein, in the 1 to 330 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

MRGX2, MRGPRX2, Mas-related G-protein coupled receptor member X2

1 Images
SDS-PAGE - Recombinant Human GPCR MRGX2 protein (AB165129)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GPCR MRGX2 protein (AB165129)

ab165129 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q96LB1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MDPTTPAWGTESTTVNGNDQAPLLLCGKETLIPVFLILFIALVGLVGNGFVLWLLGFRMRRNAFSVYVLSLAGADFLFLCFQIINCLVYLSNFFCSISINFPSFFTTVMTCAYLAGLSMLSTVSTERCLSVLWPIWYRCRRPRHLSAVVCVLLWALSLLLSILEGKFCGFLFSDGDSGWCQTFDFITAAWLIFLFMVLCGSSLALLVRILCGSRGLPLTRLYLTILLTVLVFLLCGLPFGIQWFLILWIWKDSDVLFCHIHPVSVVLSSLNSSANPIIYFFVGSFRKQWRLQQPILKLALQRALQDIAEVDHSEGCFRQGTPEMSRSSLV","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":330,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96LB1","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

G protein-coupled receptor MRGX2 also known as MAS-related GPR member X2 is a protein involved in signaling processes. This receptor has a mass of around 37 kDa and is part of the large GPCR family known for transmitting signals from outside to inside the cell. MRGX2 expresses primarily in sensory neurons of the dorsal root ganglia and skin mast cells where it plays a significant role in sensory perception and inflammatory responses.
Biological function summary

MRGX2 functions by interacting with a variety of neuropeptides and small molecules acting as a mediator of itch and pain. This receptor is involved in mast cell degranulation making it a part of the immune response complex. It helps regulate the release of histamines and other inflammatory mediators contributing to the body's defense mechanisms against various stimuli.

Pathways

MRGX2 is an essential component in the G protein-coupled receptor signaling pathway particularly influencing the PI3K/AKT signaling cascade. This pathway includes interactions with related proteins like phosphoinositide-dependent kinase-1 and AKT1 which are important for cell survival and growth. MRGX2's involvement in these pathways underlines its importance in mediating responses to allergic and inflammatory triggers.

MRGX2 has been implicated in chronic pruritus and atopic dermatitis conditions marked by persistent itch and inflammation. Its interaction with other receptors such as the histamine H1 receptor demonstrates its role in these dermatological issues. Understanding MRGX2's role and related pathways offers potential therapeutic targets for managing these skin disorders effectively.
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Specifications

Form

Liquid

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General info

Function

Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed : 25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

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Product protocols

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Target data

Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed : 25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.
See full target information MRGPRX2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Clinical and translational allergy 10:61 PubMed33298187

2020

A novel ELISA method to determine human MrgX2 in chronic urticaria.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Ding,Tao Zhang,Rui Liu,Delu Che,Nan Wang,Langchong He
View all publications
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