Recombinant Human GPCR TGR7 protein (GST tag N-Terminus)
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Recombinant Human GPCR TGR7 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 321 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
MRGD, MRGPRD, Mas-related G-protein coupled receptor member D, Beta-alanine receptor, G-protein coupled receptor TGR7
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human GPCR TGR7 protein (GST tag N-Terminus) (AB165111)
ab165111 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TGR7 plays a role in pain transmission and modulation processes. The receptor is involved in nociception which contributes to the detection of noxious stimuli and transmits the signal to the central nervous system. Researchers believe it functions as a single unit without forming part of a larger protein complex. TGR7 modulates the pathways involved in pain perception and inflammatory responses.
Pathways
TGR7 is involved in the pain and inflammation pathways. It interacts with multiple intracellular signaling proteins such as G-proteins that relay signals leading to physiological responses. The receptor shares connections with proteins like TRPV1 which also participate in pain signaling pathways. These pathways highlight TGR7's critical role in translating external stimuli into cellular responses.
Specifications
Form
Liquid
General info
Function
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Target data
Product promise
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