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AB113595

Recombinant Human GPD1L protein

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(1 Publication)

Recombinant Human GPD1L protein is a Human Full Length protein, in the 1 to 351 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

KIAA0089, GPD1L, Glycerol-3-phosphate dehydrogenase 1-like protein, GPD1-L

1 Images
SDS-PAGE - Recombinant Human GPD1L protein (AB113595)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GPD1L protein (AB113595)

15% SDS-PAGE analysis of ab113595 (3μg)

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q8N335

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT","proteinLength":"Full Length","predictedMolecularWeight":"40.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":351,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8N335","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein GPD1L also known as glycerol-3-phosphate dehydrogenase 1-like protein plays an enzymatic role in converting L-glycerol-3-phosphate to dihydroxyacetone phosphate while reducing NAD+ to NADH. Its molecular mass is approximately 39 kDa. GPD1L is expressed in the heart muscle and various other tissues. Its expression levels vary depending on the tissue indicating different roles in various biological environments.
Biological function summary

GPD1L affects several metabolic processes which are essential for cellular energy balance and homeostasis. It does not form a known complex but interacts with cellular components influencing metabolic flux. By acting as part of redox reactions it helps in maintaining the balance of redox states in cells. It also affects ion channels by modulating sodium current density in cardiac tissues which is important for heart function.

Pathways

GPD1L participates in metabolic and signaling pathways. It is integral to the glycerophosphate shuttle pathway helping in transferring reducing equivalents into mitochondria for ATP production. In addition it has a role in cardiac conduction and regulation of ion channels particularly in conjunction with the protein SCN5A which affects sodium ion flow and heart rhythm.

GPD1L is linked to cardiac arrhythmias such as Brugada syndrome. Mutations in the GPD1L gene can disrupt sodium current which is often associated with irregular heartbeats and increased risk of sudden cardiac death. Its relationship with the SCN5A protein is significant as mutations in SCN5A also contribute to similar cardiac conditions by affecting sodium channel function and predisposition to arrhythmias.
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Specifications

Form

Liquid

Additional notes

ab113595 was purified using conventional chromatography.

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General info

Function

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

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Product protocols

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Target data

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
See full target information GPD1L
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 15:1582728 PubMed40538846

2025

GPD1L downregulation in colorectal cancer: a novel obesity-related biomarker linking metabolic dysregulation to tumor progression.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Zhu,Huiyuan Li,Hongzhang Liu,Yusheng Wang
View all publications
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