Recombinant Human GPHA2 protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPHA2 also known as Glycoprotein Hormone Alpha-2 serves as a subunit of heterodimeric glycoprotein hormones. It has a molecular mass of around 14 kDa. GPHA2 is expressed in various tissues including the pituitary gland testes and placenta. It partners with the beta subunits of different hormones such as TSH LH FSH and CG playing critical roles in hormonal activity.

Biological function summary

The GPHA2 forms a non-covalent complex with its respective beta subunits. As a part of these hormones GPHA2 influences multiple biological processes such as endocrine regulation. It helps mediate reproduction growth and metabolism by promoting signal transduction through receptor binding. This activity makes it an essential player in the functionality of several physiological systems.

Pathways

GPHA2 participates in signal transduction pathways linked to hormone reception and activation. It integrates into the pituitary-gonadal axis and the thyroid-stimulating hormone pathways. These pathways involve proteins like Luteinizing Hormone Beta (LHB) and Thyrotropin Receptor (TSHR) connecting biological signals from the brain to peripheral organs.

GPHA2 has associations with conditions such as hypopituitarism and hyperthyroidism. In hypopituitarism altered levels of glycoprotein hormones affect the target due to its role in the hormone complex formation. In hyperthyroidism excessive production of thyroid hormones implicates GPHA2 interactions with TSH and TSHR. Understanding these associations provides insight into potential therapeutic targets and treatment strategies.