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AB132899

Recombinant Human GPM6B protein (GST tag N-Terminus)

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Recombinant Human GPM6B protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 305 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

M6B, GPM6B, Neuronal membrane glycoprotein M6-b, M6b

1 Images
SDS-PAGE - Recombinant Human GPM6B protein (GST tag N-Terminus) (AB132899)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GPM6B protein (GST tag N-Terminus) (AB132899)

12.5% SDS-PAGE analysis of ab132899 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

Q13491

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB214459

Anti-GPM6B antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPM6B antibody (AB214459)

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Primary Antibodies

AB308310

Anti-SynCAM/CADM1 antibody [EPR25965-89] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-SynCAM/CADM1 antibody [EPR25965-89] - BSA and Azide free (Detector) (AB308310)

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Proteins & Peptides

AB174394

Recombinant Human PSMD11 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human PSMD11 protein (denatured) (His tag N-Terminus) (AB174394)

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Primary Antibodies

AB188329

Anti-TXNDC11/EFP1 antibody [EPR14314] - C-terminal

RabMAb|Recombinant

Immunoprecipitation - Anti-TXNDC11/EFP1 antibody [EPR14314] - C-terminal (AB188329)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MKPAMETAAEENTEQSQERKVNSRAEMEIGRYHWMYPGSKNHQYHPVPTLGDRASPLSSPGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSREDCCTKF","proteinLength":"Full Length","predictedMolecularWeight":"59.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":305,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q13491","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The glycoprotein M6B commonly known as GPM6B is a membrane glycoprotein that belongs to the proteolipid protein family. This protein has a molecular mass of approximately 33 kilodaltons. GPM6B is expressed in various tissues with a strong presence in the brain particularly in neurons and glial cells. It is also found in bone and platelets indicating its diverse roles in different physiological contexts.
Biological function summary

The glycoprotein M6B contributes to several cellular processes such as neurite outgrowth and synapse assembly. It is known to participate in myelination and cell adhesion activities. Researchers have identified GPM6B to be part of a membrane microdomain where it may work with other proteins to mediate these cellular interactions. Its role in bone homeostasis further highlights its biological significance across distinct cellular environments.

Pathways

Glycoprotein M6B is significantly involved in the calcium signaling pathway and the integrin signaling pathway. Within these pathways GPM6B works in conjunction with integrins and calcium channels influencing cellular responses to mechanical stimuli and cell-extracellular matrix adhesion. These pathways highlight GPM6B's role in maintaining cellular structure and signaling transduction as they contribute to broader cellular functionalities.

Abnormal expression or mutations of glycoprotein M6B have been linked to neurological disorders like autism spectrum disorder and the bone disease osteoporosis. The involvement of GPM6B in these conditions may also relate to its interaction with proteins such as integrins. These interactions can affect cellular procedures critically important for maintaining neural network connectivity and bone density revealing therapeutic research potential.
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Specifications

Form

Liquid

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General info

Function

May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.

Sequence similarities

Belongs to the myelin proteolipid protein family.

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Product protocols

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Target data

May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
See full target information GPM6B
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Product promise

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