Recombinant Human GPR114 protein (Fc Chimera)
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Recombinant Human GPR114 protein (Fc Chimera) is a Human Fragment protein, in the 1 to 184 aa range, expressed in HEK 293 cells, with >94%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
GPR114, PGR27, UNQ2524/PRO6017, ADGRG5, Adhesion G-protein coupled receptor G5, G-protein coupled receptor 114, G-protein coupled receptor PGR27
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human GPR114 protein (Fc Chimera) (AB276327)
SDS-PAGE analysis of ab276327.
The apparent molecular mass of the protein is approximately 56-63 kDa in SDS-PAGE under reducing conditions.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
GPR114 functions involve cell adhesion and communication. It is not part of a larger protein complex but often interacts with other membrane proteins to facilitate cell-cell interactions. The receptor plays a role in immune responses by mediating signals that impact cell migration and positioning.
Pathways
GPR114 is significantly involved in the immune response signaling pathway which helps in the regulation of immune cell behavior. Its function is closely related to other adhesion GPCR family members such as GPR116 which also contributes to immune regulation. These relationships highlight the receptor's role in activating intracellular pathways that control the immune response dynamics.
Specifications
Form
Lyophilized
General info
Function
Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking).
Sequence similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Post-translational modifications
Autoproteolysis between residues Leu-226 and Thr-227 occurs in the lumen of the endoplasmic reticulum during receptor biosynthesis. The N-terminal fragment (NTF) subsequently reassociates with the C-terminal fragment (CTF) either in a homogeneric heterodimerization, or with another family member through heterogeneric heterodimerization. Autocatalytic cleavage is thought to be critical for the maturation, stability, trafficking, and function.
Target data
Complementary Products
Product promise
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