Recombinant Human GPR2/CCR10 protein is a Human Full Length protein, in the 1 to 362 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M G T E A T E Q V S W G H Y S G D E E D A Y S A E P L P E L C Y K A D V Q A F S R A F Q P S V S L T V A A L G L A G N G L V L A T H L A A R R A A R S P T S A H L L Q L A L A D L L L A L T L P F A A A G A L Q G W S L G S A T C R T I S G L Y S A S F H A G F L F L A C I S A D R Y V A I A R A L P A G P R P S T P G R A H L V S V I V W L L S L L L A L P A L L F S Q D G Q R E G Q R R C R L I F P E G L T Q T V K G A S A V A Q V A L G F A L P L G V M V A C Y A L L G R T L L A A R G P E R R R A L R V V V A L V A A F V V L Q L P Y S L A L L L D T A D L L A A R E R S C P A S K R K D V A L L V T S G L A L A R C G L N P V L Y A F L G L R F R Q D L R R L L R G G S C P S G P Q P R R G C P R R P R L S S C S A P T E T H S L S W D N
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
Alternative names
GPR2, CCR10, C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2
Recommended products
Recombinant Human GPR2/CCR10 protein is a Human Full Length protein, in the 1 to 362 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P46092-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M G T E A T E Q V S W G H Y S G D E E D A Y S A E P L P E L C Y K A D V Q A F S R A F Q P S V S L T V A A L G L A G N G L V L A T H L A A R R A A R S P T S A H L L Q L A L A D L L L A L T L P F A A A G A L Q G W S L G S A T C R T I S G L Y S A S F H A G F L F L A C I S A D R Y V A I A R A L P A G P R P S T P G R A H L V S V I V W L L S L L L A L P A L L F S Q D G Q R E G Q R R C R L I F P E G L T Q T V K G A S A V A Q V A L G F A L P L G V M V A C Y A L L G R T L L A A R G P E R R R A L R V V V A L V A A F V V L Q L P Y S L A L L L D T A D L L A A R E R S C P A S K R K D V A L L V T S G L A L A R C G L N P V L Y A F L G L R F R Q D L R R L L R G G S C P S G P Q P R R G C P R R P R L S S C S A P T E T H S L S W D N
- Accession
- P46092
- Protein length
- Full Length
- Predicted molecular weight
- 64.8 kDa
- Amino acids
- 1 to 362
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
- Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GPR2/CCR10 also known as Chemokine Receptor 10 or CDw195 is a G protein-coupled receptor with a molecular mass of approximately 37 kDa. This receptor is expressed primarily on the surface of certain immune cells including T cells B cells and eosinophils. The presence of GPR2/CCR10 is also noted in epithelial cells found in skin and mucosal tissues suggesting a role in immune surveillance and cell trafficking within these areas.
- Biological function summary
GPR2/CCR10 interacts with specific chemokines aiding in the regulation of cell migration and positioning. It belongs to a family of receptors that form complexes with G proteins to trigger intracellular signaling pathways. This receptor plays significant roles in orchestrating immune responses through its participation in chemotaxis where it guides immune cells to sites of inflammation or injury ultimately facilitating the recruitment and positioning of immune cells.
- Pathways
GPR2/CCR10 is involved in several significant signaling cascades including the chemokine signaling pathway and the MAPK pathway. It shares functional dynamics with related receptors such as CCR4 which also binds chemokines to modulate immune cell movement. These pathways are integral in mounting effective inflammatory and immune responses where precise cell trafficking and positioning are important.
- Associated diseases and disorders
Dysfunction or abnormal expression of GPR2/CCR10 correlates with conditions like psoriasis and atopic dermatitis. In these disorders GPR2/CCR10 associates with pathways leading to excessive inflammation and immune response. The receptor also interacts with other immune-related proteins during disease pathogenesis such as CCL27 which is a chemokine ligand that binds to CCR10 directing cellular activities and influencing disease outcomes.
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1 product image
SDS-PAGE - Recombinant Human GPR2/CCR10 protein (ab131829)
12.5% SDS-PAGE analysis of ab131829 stained with Coomassie Blue.
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