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AB131829

Recombinant Human GPR2/CCR10 protein (GST tag N-Terminus)

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Recombinant Human GPR2/CCR10 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 362 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

GPR2, CCR10, C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2

1 Images
SDS-PAGE - Recombinant Human GPR2/CCR10 protein (AB131829)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GPR2/CCR10 protein (AB131829)

12.5% SDS-PAGE analysis of ab131829 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

P46092

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN","proteinLength":"Full Length","predictedMolecularWeight":"64.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":362,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P46092","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GPR2/CCR10 also known as Chemokine Receptor 10 or CDw195 is a G protein-coupled receptor with a molecular mass of approximately 37 kDa. This receptor is expressed primarily on the surface of certain immune cells including T cells B cells and eosinophils. The presence of GPR2/CCR10 is also noted in epithelial cells found in skin and mucosal tissues suggesting a role in immune surveillance and cell trafficking within these areas.
Biological function summary

GPR2/CCR10 interacts with specific chemokines aiding in the regulation of cell migration and positioning. It belongs to a family of receptors that form complexes with G proteins to trigger intracellular signaling pathways. This receptor plays significant roles in orchestrating immune responses through its participation in chemotaxis where it guides immune cells to sites of inflammation or injury ultimately facilitating the recruitment and positioning of immune cells.

Pathways

GPR2/CCR10 is involved in several significant signaling cascades including the chemokine signaling pathway and the MAPK pathway. It shares functional dynamics with related receptors such as CCR4 which also binds chemokines to modulate immune cell movement. These pathways are integral in mounting effective inflammatory and immune responses where precise cell trafficking and positioning are important.

Dysfunction or abnormal expression of GPR2/CCR10 correlates with conditions like psoriasis and atopic dermatitis. In these disorders GPR2/CCR10 associates with pathways leading to excessive inflammation and immune response. The receptor also interacts with other immune-related proteins during disease pathogenesis such as CCL27 which is a chemokine ligand that binds to CCR10 directing cellular activities and influencing disease outcomes.
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Specifications

Form

Liquid

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General info

Function

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Product protocols

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Target data

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
See full target information CCR10
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