Recombinant Human GPR84 protein
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Recombinant Human GPR84 protein is a Human Fragment protein, in the 208 to 316 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
EX33, GPR84, G-protein coupled receptor 84, Inflammation-related G-protein coupled receptor EX33
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human GPR84 protein (AB162701)
ab162701 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
GPR84 modulates immune responses and is involved in inflammation. It does not form a complex with other proteins but interacts independently to regulate the production of pro-inflammatory cytokines. The receptor has gained attention for its role in immune response specifically how it aids cells to react to fatty acids influencing both metabolism and inflammation.
Pathways
GPR84 participates in the lipid signaling pathway playing a role in fatty acid metabolism and immune regulation. It closely interacts with lipid molecules which activate the signaling cascades within inflammatory and metabolic contexts. Among related proteins it connects with other receptors such as GPR120 which is also involved in fatty acid signaling and inflammatory responses.
Specifications
Form
Liquid
General info
Function
G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10 : 0), undecanoic acid (C11 : 0) and lauric acid (C12 : 0) are the most potent agonists (PubMed : 16966319). In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B (By similarity). In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation (By similarity). Plays also an important role in inflammation by modulating neutrophil functions (By similarity). Mechanistically, promotes neutrophil chemotaxis, reactive oxygen species (ROS) production and degranulation via LYN-AKT/ERK pathway (By similarity). To regulate ROS, communicates with the two formyl peptide receptors FPR2 and FPR1 to control the NADPH oxidase activity in neutrophils (PubMed : 33789297).
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Post-translational modifications
Phosphorylated by a subset of GPR84-activating ligands. Constitutively phosphorylated at Ser-221 and Ser-224 in the absence of 2-HTP. By contrast, Thr-263 and Thr-264 are phosphorylated only following prior cell treatment with 2-HTP.
Target data
Complementary Products
Product promise
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