Recombinant Human GPx-7 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The glutathione peroxidase 7 (GPx-7) is an enzyme that plays a significant role in protecting cells from oxidative damage. Also known as PHGPx or GPX7 this enzyme belongs to the glutathione peroxidase family. It is involved in reducing hydrogen peroxide and organic hydroperoxides into less reactive molecules using glutathione as a substrate. GPx-7 has a molecular mass of approximately 23 kDa. Expression of GPx-7 is widespread with notable presence in the epithelial cells of the gastrointestinal tract and liver highlighting its potential role in detoxification processes.

Biological function summary

GPx-7 mediates the detoxification of oxidative stress within cells and contributes to maintaining cellular redox balance. It does not act as part of a major protein complex but functions independently to scavenge free radicals and prevent cellular damage. Through its peroxidase activity it helps in preventing the accumulation of harmful peroxides ensuring cellular integrity and stability. This protective mechanism is essential for normal cellular function and survival in oxidative environments.

Pathways

GPx-7 is involved in the glutathione metabolism pathway and the response to oxidative stress pathway. It works closely with other enzymes in the glutathione peroxidase family notably GPx-1 to facilitate the reduction of peroxides using glutathione. These pathways are critical for detoxifying hydrogen peroxide and play an essential role in cellular defense against oxidative damage. GPx-7's cooperation with related family members signifies a coordinated effort in antioxidant defense mechanisms within the cell.

GPx-7 is associated with cancer and neurodegenerative diseases. Abnormal expression and function of GPx-7 can contribute to the progression of these conditions as oxidative stress is a known factor in pathogenesis. In cancer reduced activity or expression of GPx-7 might lead to increased oxidative stress contributing to tumorigenesis. Similarly in neurodegenerative diseases impaired antioxidant defense due to dysfunctional GPx-7 can accelerate neuronal damage. Proteins such as GPx-3 and GPx-8 also relate to these disease mechanisms interacting within similar oxidative pathways further emphasizing the importance of the GPx enzyme family in disease outcomes.