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AB103054

Recombinant Human Grancalcin protein

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Recombinant Human Grancalcin protein is a Human Full Length protein, in the 1 to 217 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

GCL, GCA, Grancalcin

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SDS-PAGE - Recombinant Human Grancalcin protein (AB103054)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Grancalcin protein (AB103054)

SDS-PAGE of ab103054 (3µg) under reducing condition and visualized by coomassie blue stain.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P28676

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMAYPGYGGGFGNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI","proteinLength":"Full Length","predictedMolecularWeight":"26.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":217,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P28676","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Grancalcin also known as GCL or GCA is a calcium-binding protein that belongs to the penta-EF-hand family. The protein has a molecular mass of about 24 kDa. It is predominantly found in neutrophils and monocytes where it localizes to the cytosol and cell membrane upon calcium activation. Grancalcin is known for its role in calcium signaling as its function is calcium-dependent which aids in modulating cellular processes.
Biological function summary

Grancalcin is involved in the regulation of cellular adhesion mechanisms. It does not form part of a larger protein complex but it plays a critical role in integrating calcium signals that facilitate cell function. Additionally grancalcin helps in the reorganization of the cytoskeleton impacting processes like chemotaxis and phagocytosis important for immune response.

Pathways

Grancalcin plays a role in the integrin signaling pathway. It interacts with key proteins in this pathway such as talin and vinculin to mediate cell adhesion and motility. Grancalcin's regulation of calcium signals also ties it to the MAPK signaling pathway which influences various cell functions including proliferation and differentiation.

Alterations in grancalcin expression or function have connections to immune-related diseases such as chronic inflammation. Aberrant levels may also have implications in cancer metastasis where cell adhesion and motility affect tumor spread. Grancalcin's role in these conditions may involve interactions with integrin-associated proteins that modulate the mechanical properties of cells.
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Specifications

Form

Liquid

Additional notes

ab103054 was purified using conventional chromatography.

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General info

Function

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.

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Product protocols

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Target data

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.
See full target information GCA
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Product promise

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