Recombinant Human GRB7 protein
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Recombinant Human GRB7 protein is a Human Full Length protein, in the 1 to 532 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, WB.
View Alternative Names
Growth factor receptor-bound protein 7, B47, Epidermal growth factor receptor GRB-7, GRB7 adapter protein, GRB7
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human GRB7 protein (AB125569)
SDS-PAGE analysis of ab125569.
Complementary Products
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GRB7 antibody [EPR14099] (AB183737)](https://content.abcam.com/products/images/grb7-antibody-epr14099-ab183737--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img44795.jpg)
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Proteins like GRB7 interact with various cell surface receptors. GRB7 forms part of signaling complexes that modulate diverse cellular responses essential for cell communication and function. As an adapter protein GRB7 binds with SH2 and PH domains to facilitate signal transduction directly influencing cellular proliferation and movement. Its expression links with cell motility indicating its relevance in cellular responses such as migration and adhesion.
Pathways
Proteins influencing GRB7 highlight its involvement in several signaling pathways notably the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways. These pathways play important roles in regulating cellular processes like growth survival and migration. GRB7 interacts closely with other proteins such as HER2 often amplifying the signaling related to growth factors further indicating its critical role in signal transduction networks.
Specifications
Form
Liquid
Additional notes
Purity determined to be >90% by densitometry.
General info
Function
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
Sequence similarities
Belongs to the GRB7/10/14 family.
Post-translational modifications
Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases.
Target data
Product promise
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