Recombinant human Growth Hormone protein (Active) (Tag Free)
- Bioactive
- What is this?
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(1 Publication)
Recombinant human Growth Hormone protein (Active) (Tag Free) is a Human Full Length protein, in the 27 to 217 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS, WB.
View Alternative Names
Somatotropin, Growth hormone, Growth hormone 1, Pituitary growth hormone, GH, GH-N, GH1
- WB
Unknown
Western blot - Recombinant human Growth Hormone protein (Active) (Tag Free) (AB51232)
All lanes:
Western blot - Anti-Growth Hormone antibody [GH-1] (<a href='/en-us/products/primary-antibodies/growth-hormone-antibody-gh-1-ab9821'>ab9821</a>) at 1/500 dilution
Lane 1:
Western blot - Recombinant human Growth Hormone protein (Active) (Tag Free) (ab51232) at 0.1 µg
Lane 2:
Western blot - Recombinant human Growth Hormone protein (Active) (Tag Free) (ab51232) at 0.01 µg
Secondary
All lanes:
Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-mouse-igg-h-l-hrp-preadsorbed-ab97040'>ab97040</a>) at 1/5000 dilution
Predicted band size: 25 kDa
true
Exposure time: 2min
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human Growth Hormone protein (Active) (Tag Free) (AB51232)
15% SDS-PAGE - Recombinant human Growth Hormone protein (Active) (ab51232, 3 μg).
Reducing conditions. Visualized by coomassie blue stain.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
GH triggers growth and cell reproduction by exerting effects on multiple tissues. It binds to the growth hormone receptor which initiates a cascade of reactions that ultimately stimulates growth in muscle bone and cartilage. GH also contributes to protein synthesis and helps regulate metabolism. GH acts mostly independently but can interact with cytokines and other hormones.
Pathways
GH plays important roles in the regulation of the JAK-STAT signaling pathway and the IGF-1 signaling pathway. The JAK-STAT pathway is important for transmitting the signal of GH binding to its receptor into cellular responses. GH stimulates IGF-1 production in the liver and IGF-1 then acts in an endocrine manner to mediate much of GH’s growth-promoting activity. These interactions highlight the interconnectedness of GH with other hormones in growth signaling networks.
Specifications
Form
Liquid
Additional notes
Recombinant human Growth Hormone was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
General info
Function
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Sequence similarities
Belongs to the somatotropin/prolactin family.
Target data
Publications (1)
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PloS one 10:e0134723 PubMed26309247
2015
Applications
Unspecified application
Species
Unspecified reactive species
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