JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB111625

Recombinant Human GRP protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human GRP protein is a Human Full Length protein, in the 1 to 172 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

GRP, HSPC159, LGALSL, Galectin-related protein, Galectin-like protein, Lectin galactoside-binding-like protein

1 Images
SDS-PAGE - Recombinant Human GRP protein (AB111625)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GRP protein (AB111625)

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q3ZCW2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.04% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMAGSVADSDAVVKLDDGHLNNSLSSPVQADVYFPRLIVPFCGHIKGGMRPGKKVLVMGIVDLNPESFAISLTCGDSEDPPADVAIELKAVFTDRQLLRNSCISGERGEEQSAIPYFPFIPDQPFRVEILCEHPRFRVFVDGHQLFDFYHRIQTLSAIDTIKINGDLQITKLG","proteinLength":"Full Length","predictedMolecularWeight":"21.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":172,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q3ZCW2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Gastrin-releasing peptide (GRP) also known by the alternate names bombesin-like peptide or GRP protein is a neuropeptide with a molecular mass of approximately 30 kDa. GRP is predominantly expressed in the central nervous system gastrointestinal tract and certain endocrine tissues. The neuropeptide acts as a ligand for the GRP receptor facilitating the release of gastrin and promoting smooth muscle contraction in the gastrointestinal tract.
Biological function summary

Gastrin-releasing peptide influences several physiological processes including gastric acid secretion pancreatic enzyme release and intestinal motility. GRP is part of the bombesin receptor family which includes receptors that mediate various signaling pathways. It functions by binding to its respective receptors leading to activation of second messenger systems like phospholipase C which subsequently elevates intracellular calcium levels and activates protein kinases.

Pathways

Gastrin-releasing peptide plays a role in the regulation of the digestive and nervous systems' physiological pathways. In the digestive system GRP is involved in the secretion of both gastric acid and pancreatic enzymes. It conducts its function by interacting with proteins like the GRP receptor and other members of the signaling pathways. In the nervous system GRP participates in modulating neurotransmitter release and neural communication interacting closely with other regulatory proteins and receptors in these pathways.

Gastrin-releasing peptide has been associated with gastrointestinal diseases such as gastritis and colorectal cancer. Overexpression of GRP is occasionally noted in tumors and relates with abnormal proliferation due to dysregulated signaling. Additionally GRP's role in neuroendocrine tumors links it to proteins like bombesin and its receptors offering potential therapeutic targets in tumorigenesis and cancer treatment pathways.
style
left-column

Specifications

Form

Liquid

Additional notes

ab111625 was purified using conventional chromatography techniques.

style
left-column

General info

Function

Does not bind lactose, and may not bind carbohydrates.

style
left-column

Product protocols

style
left-column

Target data

Does not bind lactose, and may not bind carbohydrates.
See full target information LGALSL
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB114381

Recombinant Human GRPR protein

SDS-PAGE - Recombinant Human GRPR protein (AB114381)

  • 0
  • 0
Proteins & Peptides

AB104481

Recombinant Human SNRPD2 protein

SDS-PAGE - Recombinant Human SNRPD2 protein (AB104481)

  • 0
  • 0
Proteins & Peptides

AB134592

Recombinant Human SPSB2 protein

SDS-PAGE - Recombinant Human SPSB2 protein (AB134592)

  • 0
  • 0
Primary Antibodies

AB302891

Anti-PKC theta/PRKCQ antibody [27/PKC theta]

Recombinant|Trial Size

Immunoprecipitation - Anti-PKC theta/PRKCQ antibody [27/PKC theta] (AB302891)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com