Recombinant Human GRPR protein (GST tag N-Terminus)
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Recombinant Human GRPR protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 384 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
View Alternative Names
Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human GRPR protein (GST tag N-Terminus) (AB114381)
ab114381 analysed on a 12.5% SDS-PAGE Stained with Coomassie Blue.
Complementary Products
Proteins & Peptides
AB167850
Recombinant Human Neuromedin B protein (denatured) (His tag N-Terminus)
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Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
GRPR activates intracellular signaling pathways leading to changes in cellular activity. This includes influencing the release of hormones neurotransmitters and intestinal peptides. It is part of a signaling complex that plays roles in neuroendocrine regulation and smooth muscle contraction. GRPR also participates in the regulation of cell proliferation and migration making it an important component in both normal and pathological physiology.
Pathways
GRPR integrates into the mitogen-activated protein kinase (MAPK) cascade and the phospholipase C (PLC) pathway. These pathways regulate various functions like cell division and differentiation. GRPR closely interacts with proteins such as protein kinase C (PKC) and extracellular signal-regulated kinases (ERK) enhancing its function in those pathways. This receptor's signaling contributes significantly to cellular communication and response to external stimuli.
Specifications
Form
Liquid
General info
Function
Receptor for gastrin-releasing peptide (GRP) (PubMed : 1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Target data
Product promise
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