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AB164438

Recombinant Human GRWD1 protein

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(1 Publication)

Recombinant Human GRWD1 protein is a Human Full Length protein, in the 1 to 446 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

GRWD, KIAA1942, WDR28, GRWD1, Glutamate-rich WD repeat-containing protein 1

1 Images
SDS-PAGE - Recombinant Human GRWD1 protein (AB164438)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GRWD1 protein (AB164438)

ab164438 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9BQ67

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAARKGRRRTCETGEPMEAESGDTSSEGPAQVYLPGRGPPLREGEELVMDEEAYVLYHRAQTGAPCLSFDIVRDHLGDNRTELPLTLYLCAGTQAESAQSNRLMMLRMHNLHGTKPPPSEGSDEEEEEEDEEDEEERKPQLELAMVPHYGGINRVRVSWLGEEPVAGVWSEKGQVEVFALRRLLQVVEEPQALAAFLRDEQAQMKPIFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQITQWDLAVERDPEAGDVEADPGLADLPQQLLFVHQGETELKELHWHPQCPGLLVSTALSGFTIFRTISV","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":446,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9BQ67","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The growth regulation by estrogen in breast cancer protein (GRWD1) has a role in DNA replication and chromatin remodeling. As an approximately 52 kDa protein GRWD1 interacts with several key cellular components. It is notably expressed in tissues with high cell turnover such as the liver and spleen indicating its role in actively dividing cells. This protein expression suggests it has a significant part in cell proliferation.
Biological function summary

GRWD1 plays a role in chromatin structure modulation and ribosome biogenesis. GRWD1 is part of the histone chaperone complex impacting the correct assembly of chromatin during DNA replication and repair. This function assists cells in maintaining genomic stability which is important during active transcription and replication processes. Additionally its role in ribosome biogenesis helps ensure that cells produce sufficient proteins during growth phases.

Pathways

GRWD1 is involved in the DNA replication checkpoint and ribosome assembly pathways. It interacts with several regulatory proteins including cyclins and CDKs as part of these processes highlighting its involvement in the cell cycle. GRWD1 is part of the pathway with other proteins like RPA and MCMs ensuring DNA is accurately replicated and cell growth progresses smoothly during the cell cycle.

GRWD1 links to cancer through its involvement in chromatin remodeling defects. Dysregulation or mutations in GRWD1 can contribute to oncogenesis including breast cancer. Its association with proteins such as p53 underlines the importance of its correct function in preventing unregulated cell proliferation. Additionally irregularities in GRWD1 have been connected to ribosomopathies further implicating it in conditions resulting from aberrant ribosome assembly.
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Specifications

Form

Liquid

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General info

Function

Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed : 25990725).

Subcellular localisation

Nucleus

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Product protocols

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Target data

Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed : 25990725).
See full target information GRWD1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

mBio 12:e0343121 PubMed34933446

2021

GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.

Applications

Unspecified application

Species

Unspecified reactive species

Shan Wei,Songjian Lu,Lifan Liang,Xian Wang,Wan Li,Tingting Li,Luping Chen,Enguo Ju,Xinquan Zhang,Zhao Lai,Yufei Huang,Xinghua Lu,Shou-Jiang Gao
View all publications
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