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AB268348

Recombinant human GST-Annexin-4/ANXA4-PKN fusion protein (Active)

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Recombinant human GST-Annexin-4/ANXA4-PKN fusion protein (Active) is a Human Fragment protein, in the 578 to 942 aa range, expressed in Baculovirus infected Sf9 cells, with >85%, suitable for SDS-PAGE, FuncS.

View Alternative Names

ANX4, ANXA4, Annexin A4, 35-beta calcimedin, Annexin IV, Annexin-4, Carbohydrate-binding protein p33/p41, Chromobindin-4, Endonexin I, Lipocortin IV, P32.5, PP4-X, Placental anticoagulant protein II, Protein II, PAP-II

2 Images
Functional Studies - Recombinant human GST-Annexin-4/ANXA4-PKN fusion protein (Active) (AB268348)
  • FuncS

Supplier Data

Functional Studies - Recombinant human GST-Annexin-4/ANXA4-PKN fusion protein (Active) (AB268348)

The specific activity of ab268348 was 228.9 nmol/min/mg in a peptide kinase assay using CRENtide (KRREILSRRPSYR) as substrate.

SDS-PAGE - Recombinant human GST-Annexin-4/ANXA4-PKN fusion protein (Active) (AB268348)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human GST-Annexin-4/ANXA4-PKN fusion protein (Active) (AB268348)

SDS-PAGE analysis of ab268348.

Key facts

Purity

>85% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

Tag free

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

The specific activity of ab268348 was 228.9 nmol/min/mg in a peptide kinase assay using CRENtide (KRREILSRRPSYR) as substrate.

Accession

P09525

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

GST-Annexin-4/ANXA4-PKN fusion protein
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Sequence info

[{"sequence":"SSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":942,"aminoAcidStart":578,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"P09525","tags":[]},{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":3,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P09525","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Annexin-4 also known as ANXA4 is a member of the annexin protein family and has a molecular mass of approximately 35 kDa. This protein is a calcium-dependent phospholipid-binding protein that plays a role in membrane-related processes. Annexin-4 is widely expressed across various tissues most notably in epithelial cells of the intestine and in the lung. It is involved in the modulation of ion channels acting mechanically in cellular processes by interacting with cellular membranes.
Biological function summary

This protein participates in the mediation of cellular growth and in signaling pathways that respond to injury or stress. Annexin-4 does not typically form part of a complex but interacts with other cellular structures in its environment. It influences processes like cell migration inflammation and vesicle trafficking through these interactions. These roles contribute significantly to the maintenance of cellular homeostasis and adaptation during physiological changes.

Pathways

Annexin-4 engages in the regulation of the phospholipase A2 signaling pathway and the calcium signaling pathway. These pathways are integral to the cell's response to external stimuli and intracellular communication. Within these pathways Annexin-4 interacts with proteins such as phospholipase A2 and other annexins which are involved in the regulation of lipid metabolism and signal transduction. The interplay between these proteins supports the cell's ability to react and adapt to changes effectively.

Annexin-4 has notable associations with cancer and cystic fibrosis. The protein's altered expression can contribute to the progression of tumors by affecting cell proliferation and migration particularly in colorectal and breast cancers. Additionally in cystic fibrosis its involvement with epithelial ion transport processes connects it functionally to the cystic fibrosis transmembrane conductance regulator (CFTR) protein affecting chloride ion channels and impacting mucus viscosity. Its interactions and regulatory roles make Annexin-4 a significant target for research related to these disorders.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

Sequence similarities

Belongs to the annexin family.

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Product protocols

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Target data

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
See full target information ANXA4

Additional targets

PKN1
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