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AB93457

Recombinant Human GSTK1 protein (Tag Free)

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(1 Publication)

Recombinant Human GSTK1 protein (Tag Free) is a Human Full Length protein, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

HDCMD47P, GSTK1, Glutathione S-transferase kappa 1, GST 13-13, GST class-kappa, GSTK1-1, Glutathione S-transferase subunit 13, hGSTK1

1 Images
SDS-PAGE - Recombinant Human GSTK1 protein (Tag Free) (AB93457)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GSTK1 protein (Tag Free) (AB93457)

15% SDS-PAGE showing ab93457 at approximately 26 kDa (3 μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9Y2Q3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Product details

Previously labelled as Glutathione S Transferase kappa 1.

Sequence info

[{"sequence":"MGPLPRTVELFYDVLSPYSWLGFEILCRYQNIWNINLQLRPSLITGIMKDSGNKPPGLLPRKGLYMANDLKLLRHHLQIPIHFPKDFLSVMLEKGSLSAMRFLTAVNLEHPEMLEKASRELWMRVWSRNEDITEPQSILAAAEKAGMSAEQAQGLLEKIATPKVKNQLKETTEAACRYGAFGLPITVAHVDGQTHMLFGSDRMELLAHLLGEKWMGPIPPAVNARL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y2Q3","tags":[]}]

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GSTK1 also known as Glutathione S-transferase kappa 1 is an enzyme with a mass of approximately 26 kDa. This protein belongs to the glutathione S-transferase family which plays a significant role in detoxification processes through conjugation reactions. GSTK1 displays a broad tissue expression with abundant presence in liver and kidneys as well as other tissues which facilitates its involvement in protecting cells from oxidative stress and chemical damage.
Biological function summary

GSTK1 is part of the cellular defense mechanism against xenobiotic and oxidative stress. This enzyme participates in the neutralization of harmful compounds by facilitating their conjugation with glutathione a powerful antioxidant. GSTK1 functions independently and does not form part of a larger protein complex. Its activity is important in maintaining cellular homeostasis and preventing damage caused by reactive oxygen species.

Pathways

GSTK1 has critical involvement in glutathione metabolism and xenobiotic detoxification pathways. It interacts functionally with proteins like GSTM1 which are also part of the glutathione S-transferase family enhancing the cell’s ability to detoxify harmful substances. GSTK1 helps to modulate the cellular response to oxidative stress through these pathways ensuring protection against toxicity.

GSTK1 has been linked to conditions including cancer and liver diseases. Its detoxification role makes GSTK1 significant in cancer biology where its expression levels may influence tumor resistance to chemotherapy. Additionally GSTK1 has connections with other glutathione S-transferases like GSTP1 which have associations with similar disorders affecting cellular protection mechanisms.

Specifications

Form

Liquid

Additional notes

ab93457 is purified using conventional chromatography techniques.

General info

Function

Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds (PubMed : 14709161, PubMed : 14742434). Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB) (PubMed : 14709161).

Sequence similarities

Belongs to the GST superfamily. Kappa family.

Subcellular localisation

Peroxisome

Product protocols

Target data

Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds (PubMed : 14709161, PubMed : 14742434). Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB) (PubMed : 14709161).
See full target information GSTK1

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell chemical biology 26:449-461.e8 PubMed30713096

2019

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Lee M Booty,Justyna M Gawel,Filip Cvetko,Stuart T Caldwell,Andrew R Hall,John F Mulvey,Andrew M James,Elizabeth C Hinchy,Tracy A Prime,Sabine Arndt,Cristiane Beninca,Thomas P Bright,Menna R Clatworthy,John R Ferdinand,Hiran A Prag,Angela Logan,Julien Prudent,Thomas Krieg,Richard C Hartley,Michael P Murphy
View all publications

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