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AB99435

Recombinant Human GSTM2 protein

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Recombinant Human GSTM2 protein is a Human Full Length protein, in the 1 to 218 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

GST4, GSTM2, Glutathione S-transferase Mu 2, GST class-mu 2, GSTM2-2

1 Images
SDS-PAGE - Recombinant Human GSTM2 protein (AB99435)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human GSTM2 protein (AB99435)

15% SDS-PAGE showing ab99435 at approximately 27.9kDa (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P28161

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDFEKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPNLKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK","proteinLength":"Full Length","predictedMolecularWeight":"27.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":218,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P28161","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GSTM2 or Glutathione S-transferase Mu 2 is an enzyme with a mass of approximately 25 kDa. This protein functions mechanically by catalyzing the conjugation of glutathione to various hydrophobic and electrophilic compounds which enhances their solubility and facilitates their excretion. The enzyme is expressed in many tissues with high levels in the liver brain and lungs contributing to detoxification processes within these organs.
Biological function summary

The enzyme GSTM2 plays a critical role in cellular protection against oxidative stress and toxic compounds. It functions as part of a complex detoxification system interacting with reactive intermediates to prevent cellular damage. GSTM2 acts synergistically with other enzymes in the glutathione-dependent pathways to maintain cellular integrity and prevent damage from free radicals and peroxides.

Pathways

GSTM2 is heavily involved in cellular detoxification pathways and the metabolism of xenobiotics. It connects to the glutathione metabolism pathway working alongside proteins such as GSTP1 and GSTA1. These pathways are essential for protecting cells from oxidative damage and managing cellular responses to stress making GSTM2 an important player in maintaining cellular homeostasis.

GSTM2 has implications in cancer and asthma. Altered expression levels and polymorphisms in the GSTM2 gene can associate with increased cancer risk due to the impaired ability to detoxify carcinogens. In asthma changes in GSTM2 expression may contribute to an improper response to oxidative stress and inflammation. Related proteins like GSTP1 also share involvement in these conditions underlining the significance of the glutathione S-transferase family in disease susceptibility.
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Specifications

Form

Liquid

Additional notes

ab99435 is purified using conventional chromatography techniques.

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General info

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed : 21046276).

Sequence similarities

Belongs to the GST superfamily. Mu family.

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Product protocols

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Target data

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed : 21046276).
See full target information GSTM2
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Primary Antibodies

AB196503

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Secondary Antibodies

AB150121

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Secondary Antibodies

AB99695

Mouse monoclonal [SB62a] Anti-Rabbit IgG light chain

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Product promise

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