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AB124587

Recombinant Human GSTM3 protein (His tag N-Terminus)

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Recombinant Human GSTM3 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 225 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

GST5, GSTM3, Glutathione S-transferase Mu 3, GST class-mu 3, GSTM3-3, hGSTM3-3

1 Images
SDS-PAGE - Recombinant Human GSTM3 protein (His tag N-Terminus) (AB124587)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GSTM3 protein (His tag N-Terminus) (AB124587)

15% SDS-PAGE showing ab124587 at approximately 29.1kDa (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P21266

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLDFPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCYSSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLDEFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC","proteinLength":"Full Length","predictedMolecularWeight":"29.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":225,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P21266","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GSTM3 also known as Glutathione S-transferase Mu 3 is a protein that plays a role in detoxification processes. This enzyme belongs to the GST superfamily which assists in conjugating glutathione to hydrophobic and electrophilic compounds. GSTM3 has a molecular weight of approximately 26 kDa. It is expressed in various tissues including the brain liver and testis indicating its involvement in diverse physiological functions.
Biological function summary

GSTM3 facilitates the neutralization of reactive oxygen species protecting cells from oxidative damage. This protein interacts with intracellular substrates engaging in phase II metabolic reactions. While GSTM3 does not form larger multimeric complexes it partners with glutathione to stabilize and detoxify harmful compounds. This role highlights GSTM3’s importance within cellular defense mechanisms.

Pathways

GSTM3 participates in the xenobiotic metabolism and the glutathione pathway. These pathways involve the biotransformation of toxic substances where GSTM3 works in tandem with related proteins like CYP450 enzymes. GSTM3's activity in the glutathione pathway interconnects with the regulation of oxidative stress highlighting its part in cellular resilience against environmental challenges.

GSTM3 has connections to neurological disorders and certain cancers. Its involvement in detoxification processes links it to the neurodegenerative condition Parkinson's disease where oxidative stress plays a critical role. In certain cancers variations in GSTM3 expression levels influence tumor development and aggressiveness. GSTM3's interaction with proteins involved in these conditions such as GSTP1 offers potential insights into therapeutic strategies.
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Specifications

Form

Liquid

Additional notes

ab124587 is purified using conventional chromatography techniques.

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General info

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.

Sequence similarities

Belongs to the GST superfamily. Mu family.

Post-translational modifications

The N-terminus is blocked.

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Product protocols

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Target data

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
See full target information GSTM3
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