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AB128441

Recombinant Human GSTM5 protein

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Recombinant Human GSTM5 protein is a Human Full Length protein, in the 1 to 218 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Glutathione S-transferase Mu 5, GST class-mu 5, GSTM5-5, GSTM5

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SDS-PAGE - Recombinant Human GSTM5 protein (AB128441)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human GSTM5 protein (AB128441)

15% SDS-PAGE showing ab128441 (3 µg) at approximately 28.2 kDa.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P46439

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMPMTLGYWDIRGLAHAIRLLLEYTDSSYVEKKYTLGDAPDYDRSQWLNEKFKLGLDFPNLPYLIDGAHKITQSNAILRYIARKHNLCGETEEEKIRVDILENQVMDNHMELVRLCYDPDFEKLKPKYLEELPEKLKLYSEFLGKRPWFAGDKITFVDFLAYDVLDMKRIFEPKCLDAFLNLKDFISRFEGLKKISAYMKSSQFLRGLLFGKSATWNSK","proteinLength":"Full Length","predictedMolecularWeight":"28.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":218,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P46439","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GSTM5 also known as glutathione S-transferase Mu 5 is an enzyme that plays a pivotal role in detoxification processes. GSTM5 has a molecular mass of roughly 26 kDa. This protein belongs to the glutathione S-transferase family which are important for catalyzing the conjugation of glutathione to various substrates. GSTM5 is mainly expressed in tissues like the liver and lungs where detoxification is essential for maintaining cellular health.
Biological function summary

GSTM5 enzymes help in neutralizing toxins and products of oxidative stress by facilitating the conjugation of reduced glutathione to electrophilic compounds. GSTM5 does not function in isolation; it operates as part of the larger GST family that includes various isoforms like GSTM1 and GSTM3 sharing the responsibility of detoxifying harmful chemicals. Through its enzyme activity GSTM5 supports the protection of cells from toxic damage contributing to cellular antioxidant defense.

Pathways

GSTM5 activity contributes to the metabolic pathway involving the detoxification of xenobiotics playing a role in phase II metabolism. It is strongly connected to the glutathione conjugation pathway helping in the clearance of lipid peroxidation products. GSTM5 interacts closely with other proteins in the GST family including GSTP1 pinpointing its role in maintaining cellular redox balance and aiding in the conversion of harmful substances into more water-soluble products for excretion.

GSTM5 is associated with cancer and neurodegenerative diseases. Variations in GSTM5 expression have been linked to increased risk in the development of certain cancers given its role in detoxifying carcinogens. Moreover GSTM5 may influence the progression of neurodegenerative disorders by modulating oxidative stress responses a process where its counterpart GSTP1 also plays a significant part. Understanding GSTM5’s function can offer insights into potential therapeutic approaches for these conditions.
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Specifications

Form

Liquid

Additional notes

ab128441 is purified using conventional chromatography techniques

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General info

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Sequence similarities

Belongs to the GST superfamily. Mu family.

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Product protocols

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Target data

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
See full target information GSTM5
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Complementary Products

Primary Antibodies

AB154018

Anti-GSTM5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GSTM5 antibody (AB154018)

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