Recombinant Human GTF2A1 protein (His tag N-Terminus)
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Recombinant Human GTF2A1 protein (His tag N-Terminus) is a Human Fragment protein, in the 1 to 274 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
TF2A1, GTF2A1, Transcription initiation factor IIA subunit 1, General transcription factor IIA subunit 1, TFIIAL, Transcription initiation factor TFIIA 42 kDa subunit, TFIIA-42
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human GTF2A1 protein (His tag N-Terminus) (AB174399)
15% SDS-PAGE analysis of ab174399 (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
GTF2A1 assists in the accurate transcription start site selection and transcription regulation. This protein often associates with TBP and other transcription factors such as TFIIE and TFIIF forming part of the transcription preinitiation complex. It helps enhance the affinity of TBP for the TATA box a critical component in transcription initiation.
Pathways
Transcription factor GTF2A1 participates in the transcriptional regulation process. It interacts significantly within the general RNA polymerase II transcription machinery and influences pathways like the Wnt signaling pathway. GTF2A1 works closely with TFIIE and other general transcription factors in these pathways to regulate gene expression.
Specifications
Form
Liquid
Additional notes
ab174399 is purified using conventional chromatography techniques.
General info
Function
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
Sequence similarities
Belongs to the TFIIA subunit 1 family.
Post-translational modifications
The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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