Recombinant Human GTL3B protein

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

GTL3B also known as glycosyltransferase-like 3B functions as an enzyme that is involved in the modification of glycoproteins. This enzyme approximately 47 kDa in mass facilitates the transfer of sugar moieties onto target molecules which changes their glycosylation pattern. It's expressed widely in human tissues with notable levels in the liver and kidney where it takes part in important metabolic processes.

Biological function summary

GTL3B plays an important role in regulating cell-cell interactions signaling pathways and protein stability by altering glycoprotein composition. This protein acts as a part of a larger enzymatic complex that ensures proper glycosylation during protein synthesis. It also helps maintain homeostasis of cellular environments by adjusting glycoprotein structures which are necessary for normal cellular functions.

Pathways

GTL3B activity is central to the N-glycan biosynthesis and protein processing pathways. Through these processes GTL3B interacts with other proteins such as glycosyltransferases GT1 and GT2 which also contribute to modifying glycoproteins in the endoplasmic reticulum and Golgi apparatus. Its function in these pathways makes it essential for cellular communication and molecular transport within the body.

Associated diseases and disorders

Alterations in GTL3B expression cause various complications including congenital disorders of glycosylation and potential implications in cancer development. Abnormal glycosylation patterns due to GTL3B dysregulation affect proteins like alpha-1 antitrypsin and immunoglobulins which relate to these diseases. Studying GTL3B helps in understanding such diseases better and guide therapeutic developments.