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AB180332

Recombinant Human GTSF1 protein

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Recombinant Human GTSF1 protein is a Human Full Length protein, in the 1 to 167 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

FAM112B, GTSF1, Gametocyte-specific factor 1, Protein FAM112B

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SDS-PAGE - Recombinant Human GTSF1 protein (AB180332)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GTSF1 protein (AB180332)

15% SDS-PAGE analysis of ab180332 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q8WW33

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEETYTDSLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVASKLATCPFNARHQVPRAEISHHISSCDDRSCIEQDVVNQTRSLRQETLAESTWQCPPCDEDWDKDLWEQTSTPFVWGTTHYSDNNSPASNIVTEHKNNLASGMRVPKSLPYVLPWKNNGNAQ","proteinLength":"Full Length","predictedMolecularWeight":"21.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":167,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WW33","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GTSF1 also known as gametocyte specific factor 1 functions mechanically in the regulation of gene expression particularly in the germ cells. It is a protein with a molecular mass of approximately 29 kDa. GTSF1 expresses mainly in the testes and ovaries suggesting its role in reproductive biology. This target's interaction with nucleic acids is an important part of its function as it plays a role in maintaining genomic stability during gametogenesis.
Biological function summary

In the context of germ cell development GTSF1 interacts with the Piwi-interacting RNA (piRNA) pathway. It is part of a larger protein complex that influences RNA silencing playing a significant role in repressing transposable elements. This activity helps protect the integrity of the genome by preventing harmful genetic instability. The protein complex involving GTSF1 is important for the correct progression of gametogenesis impacting fertility and reproductive success.

Pathways

The involvement of GTSF1 in the piRNA pathway is essential for the silencing mechanism that targets transposable elements. This pathway is integral to maintaining germ cell genome integrity. GTSF1 works alongside other proteins like PIWI which aids in assembling the piRNA-induced silencing complex (piRISC). Through this involvement GTSF1 contributes to a downstream effect on various biosynthesis and protective mechanisms that ensure proper cell cycle progression.

Disrupted GTSF1 function is linked to reproductive health issues including infertility. Defects in piRNA pathway components related to GTSF1 failure may result in germ cell apoptosis or suboptimal gamete production. Furthermore malfunction in GTSF1 interactions could relate to gynecological disorders. GTSF1's interaction with PIWI proteins also ties it to cancer as abnormalities in piRNA pathways are sometimes observed in tumorigenesis due to their role in genomic stability.
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Specifications

Form

Liquid

Additional notes

ab180332 is purified using conventional chromatography techniques.

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General info

Function

Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.

Sequence similarities

Belongs to the UPF0224 (FAM112) family.

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Product protocols

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Target data

Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells.
See full target information GTSF1
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