Recombinant Human Guanylate kinase protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Guanylate kinase plays a central role in nucleotide metabolism specifically in the recycling of guanine nucleotides. It is not part of a larger protein complex but it interacts closely with nucleotides to maintain proper cellular energy balance. By ensuring a steady supply of GDP it supports the synthesis of other nucleotides such as GTP which are important for multiple cellular processes including protein synthesis and cell signaling. Its activity is essential for cell growth and division emphasizing its significance in cellular homeostasis.

Pathways

Guanylate kinase participates in the purine salvage pathway and the nucleotide metabolism pathway. In these pathways it collaborates with enzymes like adenylate kinase and IMP dehydrogenase. The enzyme plays a role in connecting the initial phosphate donor ATP to the synthesis of GTP. Through these mechanisms guanylate kinase influences energy transfer processes and impacts cellular functions where GTP is used as a molecular switch.