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AB134881

Recombinant Human H Cadherin protein

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Recombinant Human H Cadherin protein is a Human Full Length protein, in the 139 to 693 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

CDHH, CDH13, Cadherin-13, Heart cadherin, P105, Truncated cadherin, H-cadherin, T-cad, T-cadherin

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus T7 tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P55290

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASMTGGQQMGRGHHHHHHGNLYFQGGEFELSIVVSPILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLNINPINGTVDTTAVLDRESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLSVVILGASDKDLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCRNSKVDCNAAG","proteinLength":"Full Length","predictedMolecularWeight":"64.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":693,"aminoAcidStart":139,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P55290","tags":[{"tag":"His","terminus":"N-Terminus"},{"tag":"T7","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

H Cadherin also known as Cadherin-13 or T-cadherin is a unique member of the cadherin family of cell adhesion molecules. It weighs approximately 95 kDa. Unlike classical cadherins H Cadherin lacks the transmembrane and cytoplasmic domains anchoring instead to the membrane via a glycosylphosphatidylinositol (GPI) anchor. H Cadherin expresses in various tissues including endothelial cells cardiac muscle and neurons suggesting its versatile role in different biological contexts.
Biological function summary

The protein plays a role in cell-cell interactions and tissue organization without forming typical adherens junctions. Researchers have identified H Cadherin as a part of the significant complex involved in neural network formation vascular patterning and cardiac tissue integrity. In neurons its expression modulates axon growth and guidance. In the cardiovascular system it contributes to heart function and blood vessel maintenance through its adhesive properties and involvement in signaling pathways.

Pathways

Several biological networks incorporate H Cadherin as an important element. Notably it participates in the Wnt signaling and PI3K/AKT pathways. H Cadherin interacts with proteins such as β-catenin in the Wnt pathway influencing cellular responses like proliferation and differentiation. In the PI3K/AKT pathway the protein may affect cell survival and metabolism. These interactions illustrate H Cadherin's involvement in important cellular processes.

H Cadherin has significant associations with cardiovascular diseases and certain cancers. Altered expression levels or mutations in H Cadherin can disrupt cellular adhesion and signaling contributing to the progression of atherosclerosis and tumor formation. In cancer linkages between H Cadherin and other cadherin family members like E-cadherin suggest complex interactions that can modulate tumor cell behavior influencing invasion and metastasis.
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Specifications

Form

Liquid

Additional notes

ab134881 was refolded using “temperature shift inclusion body refolding” technology, chromatographically purified and sterile-filtered.

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General info

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

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Product protocols

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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
See full target information CDH13
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Complementary Products

Primary Antibodies

AB249422

Anti-H Cadherin antibody [EPR9621] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-H Cadherin antibody [EPR9621] - BSA and Azide free (AB249422)

  • 0
  • 0
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Multiplex Kits

AB134004

Human MMP Antibody Array - Membrane (10 Targets)

Multiplex Protein Detection - Human MMP Antibody Array - Membrane (10 Targets) (AB134004)

  • 0
  • 0
Multiplex Kits

AB133997

Cytokine Array - Human Cytokine Antibody Array (Membrane, 42 Targets)

Multiplex Protein Detection - Cytokine Array - Human Cytokine Antibody Array (Membrane, 42 Targets) (AB133997)

  • 0
  • 0

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