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AB239568

Recombinant Human HAO2 protein (His tag)

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Recombinant Human HAO2 protein (His tag) is a Human Full Length protein, in the 2 to 351 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
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SDS-PAGE - Recombinant Human HAO2 protein (His tag) (AB239568)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human HAO2 protein (His tag) (AB239568)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab239568.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NYQ3-1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Bioactive

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"SLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRYLRDVSEVDTRTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITSTFASCSLEDIVIAAPEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRHDIRNQLRRNLTLTDLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQGIIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLGRPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSRL","proteinLength":"Full Length","predictedMolecularWeight":"54.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":351,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NYQ3","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Liquid
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HAO2 protein also known as hydroxyacid oxidase 2 plays an enzyme role in the cellular environment. It catalyzes the oxidation of glycolate to glyoxylate which involves the substrate binding and conversion. With a molecular mass approximately 40 kDa HAO2 expresses mainly in tissues like liver and pancreas where it supports metabolic processes. Understanding its precise mechanical role helps clarify its action in metabolic pathways.
Biological function summary

HAO2 functions as a significant part of the peroxisomal beta-oxidation process. It does not seem to act as a component of a larger protein complex; it rather operates independently in modifying substrates. Its actions contribute to the regulation of cellular pH and reactive oxygen species through its enzymatic reactions. HAO2’s activity impacts cellular energy balance by participating in specific metabolic processes involving medium-chain hydroxy acids.

Pathways

HAO2 integrates into the metabolic pathway of glyoxylate and dicarboxylate metabolism where it executes important reactions involving hydroxy acids. In addition HAO2 co-functions with proteins such as lactate dehydrogenase in the related energy metabolism pathways aiding in energy production and balance within cells. These interconnected pathways exhibit how HAO2 supports metabolic function and stability.

HAO2 shows relevance in metabolic disorders such as primary hyperoxaluria. This condition results from an overproduction of oxalate due to defective substrate metabolism where HAO2 acts. Furthermore aberrant HAO2 function associates with renal issues due to its role in oxalate metabolism. In this context HAO2 has an indirect connection to proteins like alanine-glyoxylate aminotransferase which also impacts oxalate metabolism linking them through the biological disorder framework.
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Product protocols

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Target data

Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, to the correspondong 2-oxoacids (PubMed : 10777549). Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation (Probable). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2. Is not active on glycolate, glyoxylate, L-lactate and 2-hydroxybutanoate (PubMed : 10777549).
See full target information HAO2

Alternative Names

HAOX2, GIG16, HAO2, 2-Hydroxyacid oxidase 2, Cell growth-inhibiting gene 16 protein, Long chain alpha-hydroxy acid oxidase, Long-chain L-2-hydroxy acid oxidase
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