Recombinant Human HBP protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HBP also known as Heparanase is an enzyme that actively cleaves heparan sulfate on the cell surface and within the extracellular matrix. The protein has a molecular mass of approximately 50 kDa in its inactive form and 8 kDa in its active form after enzymatic processing. Expression of HBP is found in a variety of tissues including the placenta platelets and certain tumor cells. By breaking down heparan sulfate HBP plays a direct role in remodeling the extracellular matrix and modifying cell-matrix interactions.

Biological function summary

HBP raises the release of growth factors immobilized within the extracellular matrix which subsequently initiates angiogenesis and tissue repair processes. Heparanase forms part of a protein complex that includes proteins like syndecans and integrins enabling its functions in cellular signaling events. The enzyme is important for normal physiological processes such as inflammation and wound healing due to its tissue remodeling capabilities.

Pathways

Heparanase functions as a significant regulator in pathways involving the degradation and rebuilding of the extracellular matrix. The enzyme influences both the angiogenesis pathway and the cell-signaling pathway connected with growth factor activation. Related proteins in these pathways include matrix metalloproteinases (MMPs) which work together with HBP to facilitate tissue invasion and remodeling. These activities highlight the protein's importance in physiological and pathological processes.

Heparanase serves a noted role in cancer progression and metastasis. The enzyme enables tumor cells to infiltrate tissues by breaking down the extracellular matrix components. Additionally HBP is associated with inflammatory diseases like arthritis where it helps in leukocyte migration. Proteins like cytokines are often linked with HBP in these contexts as they are co-regulators of inflammatory responses and cancer dissemination.