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AB267899

Recombinant Human hCG receptor/LHR protein (His tag)

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Recombinant Human hCG receptor/LHR protein (His tag) is a Human Fragment protein, in the 27 to 363 aa range, expressed in Mammalian, suitable for SDS-PAGE.

View Alternative Names

LCGR, LGR2, LHRHR, LHCGR, Lutropin-choriogonadotropic hormone receptor, LH/CG-R, Luteinizing hormone receptor, LHR, LSH-R

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SDS-PAGE - Recombinant Human hCG receptor/LHR protein (His tag) (AB267899)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human hCG receptor/LHR protein (His tag) (AB267899)

SDS-PAGE analysis of ab267899 under reducing conditions.

Key facts

Expression system

Mammalian

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P22888

Animal free

No

Carrier free

No

Species

Human

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"EALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLR","proteinLength":"Fragment","predictedMolecularWeight":"41.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":363,"aminoAcidStart":27,"nature":"Recombinant","expressionSystem":"Mammalian","accessionNumber":"P22888","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The hCG receptor also known as LHR LHCGR or LH/CG receptor belongs to the G-protein coupled receptor family and is essential for reproductive processes. It has a mass of around 85 kDa and it is expressed mostly in the ovaries and testes. The receptor binds to the hCG protein also referred to as human chorionic gonadotropin and LH luteinizing hormone. Both the hCG protein and the hCG peptide stimulate the receptor leading to various reproductive functions. The anti-LHR antibodies target this receptor specifically allowing for detailed study and potential clinical applications.
Biological function summary

The hCG receptor plays a significant role in mediating reproductive hormone signaling. As part of a complex with the hCG protein it facilitates the regulation of steroidogenesis and gametogenesis. In females the activation of LHR by the hCG hormone results in the maintenance of the corpus luteum important for progesterone production in early pregnancy. Meanwhile in males LHR influences testosterone production by Leydig cells impacting spermatogenesis significantly.

Pathways

The hCG receptor significantly affects reproductive endocrine pathways that include the cAMP/PKA signaling pathway. Through this pathway the receptor interacts with several related proteins such as adenylate cyclase which further activates cAMP production. The activation of protein kinase A (PKA) facilitates downstream signaling events essential in the ovulation and spermatogenesis processes. The synergy between the hCG receptor and these pathways underlines its biological significance.

The hCG receptor is associated with reproductive health issues like infertility and polycystic ovary syndrome (PCOS). Dysregulation or mutations in LHR can disrupt normal reproductive functions and lead to these disorders. The receptor's interaction with proteins such as FSH receptor (FSHR) further influences the manifestation of these conditions making it a target for therapeutic interventions in reproductive medicine both in clinics and private labs in various places including hCG-focused research in Mexico.
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Specifications

Additional notes

nan

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General info

Function

Receptor for lutropin-choriogonadotropic hormone (PubMed : 11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed : 11847099).

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.

Post-translational modifications

Sulfated.

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Product protocols

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Target data

Receptor for lutropin-choriogonadotropic hormone (PubMed : 11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed : 11847099).
See full target information LHCGR
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