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AB101113

Recombinant Human HDAC11/HD11 protein

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Recombinant Human HDAC11/HD11 protein is a Human Full Length protein, in the 1 to 347 aa range, expressed in Baculovirus infected insect cells, with >75%, suitable for SDS-PAGE, WB, FuncS.

View Alternative Names

Histone deacetylase 11, HD11, HDAC11

3 Images
Functional Studies - Recombinant Human HDAC11/HD11 protein (AB101113)
  • FuncS

Unknown

Functional Studies - Recombinant Human HDAC11/HD11 protein (AB101113)

The specific activity of ab101113 was determined to be 52 RLU/min/ng.

Western blot - Recombinant Human HDAC11/HD11 protein (AB101113)
  • WB

Unknown

Western blot - Recombinant Human HDAC11/HD11 protein (AB101113)

ab87765 recognizes the full length tagged recombinant HDAC11 / HD11 protein (ab101113) which has an expected molecular weight of 66 kDa.

All lanes:

Anti-HDAC11/HD11 antibody (<a href='/en-us/products/unavailable/hdac11hd11-antibody-ab87765'>ab87765</a>) at 1 µg/mL

All lanes:

Western blot - Recombinant Human HDAC11/HD11 protein (ab101113) at 0.1 µg

Secondary

All lanes:

Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution

true

Exposure time: 1min

SDS-PAGE - Recombinant Human HDAC11/HD11 protein (AB101113)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human HDAC11/HD11 protein (AB101113)

The putity of ab101113 was determined to be >75% by densitometry.

Approximate MWt : 66kDa

Key facts

Purity

>75% SDS-PAGE

Expression system

Baculovirus infected insect cells

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE, FuncS

applications

Biologically active

No

Accession

Q96DB2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.307% Glutathione, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00292% EDTA, 0.00174% PMSF

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>ab101113 can be used as a WB positive control in conjunction with <a href='/en-us/products/unavailable/hdac11hd11-antibody-ab87765'>ab87765</a>.</p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

52 RLU/min/ngPreviously labelled as HDAC11.
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Sequence info

[{"linker":null,"sequence":"MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP","proteinLength":"Full Length","predictedMolecularWeight":"66 kDa","actualMolecularWeight":null,"aminoAcidEnd":347,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"Q96DB2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HDAC11 also known as HD11 is a unique member of the histone deacetylase family. HDAC11 is an enzyme involved in removing acetyl groups from lysine residues on histone tails affecting chromatin structure and gene expression. It has a molecular mass of approximately 39 kDa. You can find HDAC11 expressed in various tissues but it shows higher expression levels in brain heart skeletal muscles and kidneys indicating its significance in these organs.
Biological function summary

HDAC11 participates in the regulation of gene expression by modulating histone acetylation levels. It often functions as a part of large protein complexes that include other histone deacetylases and transcriptional co-repressors. By altering acetylation status HDAC11 can influence epigenetic regulation and thereby affect numerous cellular processes such as cell cycle progression differentiation and apoptosis. Its activity contributes to maintaining cellular homeostasis.

Pathways

HDAC11 plays a role in key signaling pathways such as the DNA damage response and inflammatory pathways. In the DNA damage response pathway HDAC11 interacts with proteins like HDAC1 and HDAC2 which are essential for DNA repair processes. Additionally in inflammatory pathways HDAC11 regulates cytokine expression and immune cell function highlighting its role in immune response modulation.

Researchers have linked HDAC11 to cancer and autoimmune diseases. Its abnormal expression or activity has associations with various cancer types including brain and kidney cancers where it potentially influences tumor progression through interaction with proteins like p53. In autoimmune diseases HDAC11 affects immune cell regulation and cytokine production interacting with immune-related proteins which may contribute to disease development and progression.
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Specifications

Form

Liquid

Additional notes

The purity was determined to be >75% by densitometry. Affinity purified.

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General info

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Sequence similarities

Belongs to the histone deacetylase family.

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Product protocols

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Target data

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
See full target information HDAC11
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Product promise

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