JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB187615

Recombinant Human HDDC2 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human HDDC2 protein is a Human Full Length protein, in the 1 to 204 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C6orf74, NS5ATP2, CGI-130, HDDC2, 5'-deoxynucleotidase HDDC2, HD domain-containing protein 2, Hepatitis C virus NS5A-transactivated protein 2, HCV NS5A-transactivated protein 2

1 Images
SDS-PAGE - Recombinant Human HDDC2 protein (AB187615)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human HDDC2 protein (AB187615)

15% SDS-PAGE (ab187615 at 3μg)

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q7Z4H3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMASVSSATFSGHGARSLLQFLRLVGQLKRVPRTGWVYRNVQRPESVSDHMYRMAVMAMVIKDDRLNKDRCVRLALVHDMAECIVGDIAPADNIPKEEKHRREEEAMKQITQLLPEDLRKELYELWEEYETQSSAEAKFVKQLDQCEMILQASEYEDLEHKPGRLQDFYDSTAGKFNHPEIVQLVSELEAERSTNIAAAASEPHS","proteinLength":"Full Length","predictedMolecularWeight":"25.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":204,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q7Z4H3","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HDDC2 protein also known as HD domain containing 2 has a molecular weight of approximately 22 kDa. Mechanically HDDC2 functions as a hydrolase enzyme with a role in nucleotide metabolism. It is expressed mostly in tissues like the brain and kidney. This protein is important for maintaining cellular nucleotide balance and participates in hydrolytic activities breaking down specific nucleotide substrates.
Biological function summary

HDDC2 participates in regulating nucleotide turnover and cellular responses to nucleotide imbalances. It contributes to metabolizing nucleic acids ensuring proper cellular function and viability. HDDC2 often works as part of a larger enzymatic complex that includes other nucleotide metabolizing enzymes. This cooperative activity helps maintain a stable environment for nucleotide availability and recycling.

Pathways

HDDC2 integrates into the nucleotide metabolism pathway which includes the salvage of nucleotides and their degradation. While functioning within these pathways HDDC2 has interactions with proteins involved in nucleotide biosynthesis and catabolism such as the ribonucleotide reductase family. These interactions signify its fundamental role in facilitating balance between nucleotide synthesis and degradation therefore supporting DNA replication and repair processes.

HDDC2 may have potential links to neurological disorders and certain cancers. Deficiencies or dysregulation of HDDC2 could contribute to nucleotide imbalance-related pathologies potentially affecting neuronal function or promoting tumorigenesis. It may interact with tumor suppressor proteins such as p53 which plays a role in cellular stress responses. Understanding these connections could provide insight into HDDC2’s involvement in disease mechanisms.

Specifications

Form

Liquid

General info

Function

Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).

Sequence similarities

Belongs to the HDDC2 family.

Product protocols

Target data

Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
See full target information HDDC2

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com