Recombinant Human HDDC2 protein is a Human Full Length protein, in the 1 to 204 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M A S V S S A T F S G H G A R S L L Q F L R L V G Q L K R V P R T G W V Y R N V Q R P E S V S D H M Y R M A V M A M V I K D D R L N K D R C V R L A L V H D M A E C I V G D I A P A D N I P K E E K H R R E E E A M K Q I T Q L L P E D L R K E L Y E L W E E Y E T Q S S A E A K F V K Q L D Q C E M I L Q A S E Y E D L E H K P G R L Q D F Y D S T A G K F N H P E I V Q L V S E L E A E R S T N I A A A A S E P H S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
Alternative names
C6orf74, NS5ATP2, CGI-130, HDDC2, 5'-deoxynucleotidase HDDC2, HD domain-containing protein 2, Hepatitis C virus NS5A-transactivated protein 2, HCV NS5A-transactivated protein 2
Recommended products
Recombinant Human HDDC2 protein is a Human Full Length protein, in the 1 to 204 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q7Z4H3-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 89% PBS, 10% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M A S V S S A T F S G H G A R S L L Q F L R L V G Q L K R V P R T G W V Y R N V Q R P E S V S D H M Y R M A V M A M V I K D D R L N K D R C V R L A L V H D M A E C I V G D I A P A D N I P K E E K H R R E E E A M K Q I T Q L L P E D L R K E L Y E L W E E Y E T Q S S A E A K F V K Q L D Q C E M I L Q A S E Y E D L E H K P G R L Q D F Y D S T A G K F N H P E I V Q L V S E L E A E R S T N I A A A A S E P H S
- Accession
- Q7Z4H3
- Protein length
- Full Length
- Predicted molecular weight
- 25.8 kDa
- Amino acids
- 1 to 204
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
- Sequence similarities
Belongs to the HDDC2 family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The HDDC2 protein also known as HD domain containing 2 has a molecular weight of approximately 22 kDa. Mechanically HDDC2 functions as a hydrolase enzyme with a role in nucleotide metabolism. It is expressed mostly in tissues like the brain and kidney. This protein is important for maintaining cellular nucleotide balance and participates in hydrolytic activities breaking down specific nucleotide substrates.
- Biological function summary
HDDC2 participates in regulating nucleotide turnover and cellular responses to nucleotide imbalances. It contributes to metabolizing nucleic acids ensuring proper cellular function and viability. HDDC2 often works as part of a larger enzymatic complex that includes other nucleotide metabolizing enzymes. This cooperative activity helps maintain a stable environment for nucleotide availability and recycling.
- Pathways
HDDC2 integrates into the nucleotide metabolism pathway which includes the salvage of nucleotides and their degradation. While functioning within these pathways HDDC2 has interactions with proteins involved in nucleotide biosynthesis and catabolism such as the ribonucleotide reductase family. These interactions signify its fundamental role in facilitating balance between nucleotide synthesis and degradation therefore supporting DNA replication and repair processes.
- Associated diseases and disorders
HDDC2 may have potential links to neurological disorders and certain cancers. Deficiencies or dysregulation of HDDC2 could contribute to nucleotide imbalance-related pathologies potentially affecting neuronal function or promoting tumorigenesis. It may interact with tumor suppressor proteins such as p53 which plays a role in cellular stress responses. Understanding these connections could provide insight into HDDC2’s involvement in disease mechanisms.
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1 product image
SDS-PAGE - Recombinant Human HDDC2 protein (ab187615)
15% SDS-PAGE (ab187615 at 3μg)
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